Table 2 Gene-centric analysis showing high RV burden on T2D in the selected candidate genes

From: Excess of rare noncoding variants in several type 2 diabetes candidate genes among Asian Indian families

Method

SLC38A11

KCNJ11/ABCC8

HNF4A

P

Permuted P

P

Permuted P

P

Permuted P

CMC with Hotelling T squared test

0.029

0.037

0.006

0.003*

0.005

0.002*

0.0003

0.0002

CMC with regression

0.030

0.044

0.005

0.002*

0.007

0.002*

0.0002

0.0002

SKAT-O

0.140

–

0.068

0.025*

–

0.001

–

  1. *Rare variant burden calculated excluding less common variants rs5216 and rs376706487.
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