Fig. 3: CSF-system-wide computational pharmacokinetics for intraventricular drug delivery.
From: Computational and biological modeling of IGF1R inhibition for multifocal medulloblastoma
a Model results for a single 17 mcg dose of BMS875807 in a 2 mL bolus injected into the lateral ventricle, followed over 8 h. b, c Average drug concentration of 45.9 ng/mL and 13.2 ng/mL, over the ventricular and C1 tumor surface, respectively, computed over an 8-h time period. For reference, the EC50 of this drug for its target IGF1R IC50 1.8 nM (13.8 ng/mL), which appears yellow-red. For reference, the clinical Cmax (232 ng/mL), which appears red-dark red in (a).
