Extended Data Fig. 2: Case-control differential gene expression statistics adjusted for metabolic phenotypes, drug treatments and genotype using DESeq2.
From: A mechanistic framework for cardiometabolic and coronary artery diseases
The metabolic featured adjusted for comprised: plasma triglycerides, HbA1c, Waist/Hip ratio, plasma low-density lipoprotein (LDL) cholesterol, plasma high-density lipoprotein (HDL) cholesterol, total cholesterol, and C-reactive protein (CRP). The drug treatments adjusted for comprised as discrete categories: β-blocker, Thrombin inhibitors, Long-acting nitrate, Short-acting nitrates, ACE inhibitors or ARB, Loop diuretic, Thiazide diuretic, Lipid lowerer, Ca-channel blocker, Carvedilol, Anticoagulant, Oral antidiabetics, and Insulin. Representing population genotype, we used the first 4 components from MDS analysis of the SNP array data.
