Fig. 1: T cell- and myeloid cell-subset-specific maps emerge in the diseased aorta and aorta-draining lymph nodes. | Nature Cardiovascular Research

Fig. 1: T cell- and myeloid cell-subset-specific maps emerge in the diseased aorta and aorta-draining lymph nodes.

From: Pairing of single-cell RNA analysis and T cell antigen receptor profiling indicates breakdown of T cell tolerance checkpoints in atherosclerosis

Fig. 1

a, 13,800 T cells were grouped into ten subtypes resulting from t-SNE analyses based on their top 2,000 highly expressed genes. b, T cell-subset distribution in the t-SNE plot of WT RLNs, Apoe−/− RLNs, ATLOs and plaques. c, Percentages of all T cells of the ten subtypes within each tissue. The size of the colored section represents the percentage of each subset per total T cells. d, 2,648 myeloid cells were grouped into eight subtypes resulting from t-SNE analyses, including four DC subtypes, three monocyte/macrophage subtypes and one granulocyte subset consisting of basophils and neutrophils. e, Myeloid cell-subset distribution in t-SNE plots of WT RLNs, Apoe−/− RLNs, ATLOs and plaques. f, Percentages of eight myeloid cell subsets within each tissue. The size of the colored section represents the percentages for each subset of total myeloid cells. Statistical analysis was performed using Chi-square test with Benjamini–Hochberg correction in c and f.

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