Extended Data Fig. 9: Predicted cell-cell interactome of CD8 Tem T cells with other immune cell subsets in WT RLNs, Apoe-/- RLNs, ATLOs, plaques. | Nature Cardiovascular Research

Extended Data Fig. 9: Predicted cell-cell interactome of CD8 Tem T cells with other immune cell subsets in WT RLNs, Apoe-/- RLNs, ATLOs, plaques.

From: Pairing of single-cell RNA analysis and T cell antigen receptor profiling indicates breakdown of T cell tolerance checkpoints in atherosclerosis

Extended Data Fig. 9

a, The x axis represents the CD8 Tem T cell interaction with other immune cell subsets; the y axis depicts paired ligand-receptor interactions. Interactions contributing to T cell dysfunction in plaques when compared to WT RLNs are listed on the right. The size of circles is based on -log10 p values; color scheme is based on log2 value. b, Predicted interactions between CD8 Tem T cells with CD11b+ cDCs, pDCs, CD11c− DCs, Trem2hi macrophages, and Lyve1+ res-like macrophages in WT RLNs, Apoe-/- RLNs, ATLOs, plaques. Color scale indicates CLR-normalized expression, dot size indicates significance (-log10 p value).

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