Fig. 2: Associations of proteins, metabolites and clinical variables with IMI risk.
The associations of 817 proteins, 1,025 metabolites and 16 clinical variables with the risk of a first myocardial infarction within 6 months in the full MIMI study, adjusted for technical covariates, are shown by biomarker category (clinical, metabolite or protein). HR relates to a doubling of the concentration of proteins and metabolites and a one-unit higher level of clinical biomarkers on their original scale (for example, years, mmol l−1). The top 25 biomarkers that passed external validation and ranked on how many internal validation splits the biomarker passed the replication criteria in the model adjusted for technical covariates in addition to the external validation are highlighted. aIL-6 and bKIM1 were measured on multiple Olink panels and tested in separate statistical tests. n = 420 cases and 1,598 noncases.
