Fig. 3: A conserved KC response at the initiation of acute APOB dyslipidemia.
From: Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult
a, Transcript per million (TPM) as determined by mRNA-seq for the 10 differentially expressed genes common to both APOE cKO (n = 4 versus n = 4) and D374Y (n = 2 versus n = 2) 10 d after tamoxifen treatment. b, Expression of the conserved day 10 differentially expressed genes in myeloid cell clusters generated according to ref. 19 c, Secreted IL18BP (ng ml−1) in APOE cKO and D374Y versus respective littermate controls 10 d after tamoxifen administration (n = 4 APOE cKO and n = 5 littermate control mice; n = 6 D374Y and n = 5 littermate control mice). d, TPM values for five of the 10 conserved genes whose upregulation is maintained after 20 weeks on an HFD (n = 3 APOE cKO and n = 2 littermate control mice; n = 4 D374Y and n = 2 littermate control mice). All plots are ±s.e.m. Two-sided t-test (c). cDC, conventional dendritic cell; Mac, macrophage; Mig., migratory.
