Fig. 6: Stroke triggers platelet aggregation and vascular thrombus formation in PP.

a, 3D reconstruction images of GP1bβ⁺ platelet aggregates in CD31⁺ vasculature in PP isolated from sham, stroke+vehicle and stroke+DNase-I-treated mice. Scale bar, 300 µm. b, Quantification of GP1bβ⁺ platelet aggregates in PP isolated from sham, stroke+vehicle and stroke+DNase-I-treated mice (n = 5 PP per group, **P = 0.0027). c, 3D images showing GP1bβ⁺ platelet aggregates in CD31⁺ vasculature of PP used for analyzing surface volumes. Scale bar, 20 µm. d, Quantification of total GP1bβ⁺ platelet volumes to CD31⁺ surface volumes in PP isolated from sham, stroke+vehicle and stroke+DNase-I-treated mice (n = 5 PP per group, *P = 0.0037). Data are represented as mean ± s.d.; statistical analyses were performed by Kruskal–Wallis test.