Table 3 The relationship of creatinine and cystatin C categories with risk of incident adverse cardiovascular events

From: Different cardiovascular risks associated with elevated creatinine-based eGFR and cystatin C-based eGFR

 

Creatinine

 

Cystatin C

Low

Normal

High

 

Low

Normal

High

Cardiovascular disease

       

Events (Incidence ratesa)

2483(11.5)

35,455(8.9)

1917(8.9)

 

1633(7.5)

35,357(8.9)

2865(13.7)

Crude model

1.29(1.24, 1.35)

ref

1.01(0.96, 1.06)

 

0.84(0.80, 0.88)

ref

1.56(1.50, 1.62)

Adjusted model 1b

1.19(1.14, 1.25)

ref

1.02(0.97, 1.07)

 

0.88(0.84, 0.93)

ref

1.37(1.31, 1.42)

Adjusted model 2b

1.21(1.15, 1.26)

ref

1.01(0.96, 1.06)

 

0.91(0.86, 0.96)

ref

1.30(1.25, 1.35)

Ischemic heart disease

       

Events (Incidence ratesa)

1277(5.8)

19,252(4.8)

1067(4.8)

 

854(3.9)

19,122(4.7)

1620(7.5)

Crude model

1.22(1.15, 1.29)

ref

1.01(0.95, 1.08)

 

0.81(0.76, 0.87)

ref

1.59(1.51, 1.67)

Adjusted model 1b

1.10(1.03, 1.17)

ref

1.02(0.95, 1.09)

 

0.90(0.84, 0.97)

ref

1.31(1.24, 1.39)

Adjusted model 2b

1.11(1.04, 1.18)

ref

1.01(0.95, 1.08)

 

0.92(0.85, 0.99)

ref

1.27(1.20, 1.35)

Stroke

       

Events (Incidence ratesa)

534(2.4)

6608(1.6)

354(1.6)

 

339(1.5)

6615(1.6)

542(2.4)

Crude model

1.48(1.36, 1.62)

ref

0.98(0.88, 1.09)

 

0.94(0.84, 1.05)

ref

1.53(1.40, 1.67)

Adjusted model 1b

1.43(1.30, 1.57)

ref

0.99(0.88, 1.11)

 

0.94(0.83, 1.06)

ref

1.41(1.28, 1.56)

Adjusted model 2b

1.43(1.30, 1.57)

ref

0.99(0.88, 1.11)

 

0.93(0.82, 1.05)

ref

1.43(1.29, 1.57)

Heart failure

       

Events (Incidence ratesa)

532(2.4)

5510(1.3)

299(1.3)

 

225(1.0)

5500(1.3)

616(2.8)

Crude model

1.77(1.62, 1.94)

ref

0.99(0.88, 1.12)

 

0.75(0.65, 0.85)

ref

2.09(1.93, 2.27)

Adjusted model 1b

1.52(1.38, 1.68)

ref

0.99(0.87, 1.12)

 

0.75(0.65, 0.87)

ref

1.71(1.56, 1.87)

Adjusted model 2b

1.55(1.40, 1.71)

ref

0.98(0.86, 1.11)

 

0.81(0.70, 0.94)

ref

1.51(1.37, 1.66)

Atrial fibrillation

       

Events (Incidence ratesa)

1010(4.6)

14,340(3.5)

757(3.4)

 

666(3.0)

14,323(3.5)

1118(5.1)

Crude model

1.30(1.22, 1.38)

ref

0.96(0.90, 1.04)

 

0.85(0.79, 0.92)

ref

1.46(1.37, 1.55)

Adjusted model 1b

1.20(1.12, 1.29)

ref

0.97(0.89, 1.05)

 

0.86(0.79, 0.93)

ref

1.36(1.27, 1.45)

Adjusted model 2b

1.23(1.15, 1.32)

ref

0.95(0.88, 1.03)

 

0.92(0.84, 1.00)

ref

1.22(1.14, 1.31)

  1. aIncidence rates per 1000 person-years.
  2. bAdjusted Model 1: Adjusted for age, sex, race, systolic blood pressure, diastolic blood pressure, smoking status, history of diabetes, antihypertensive drug use, cholesterol-lowering drug use, triglycerides, total cholesterol, high-density lipoprotein cholesterol, and high-sensitivity C reactive protein; Adjusted Model 2: adjusted for the covariates in Model 1 and further adjusted for body mass index.
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