Volume 35 Issue 3, March 2025

This image symbolizes the identification of the noncanonical proteome, where scattered glimmers of light (peptides) converge to form a radiant lamp (proteome). The quest to uncover noncanonical proteins is likened to seeking a flicker of firelight in the darkness. In this study, a hidden peptidome has been unearthed and transformed into a radiant beacon, illuminating uncharted pathways for future proteomic research. See page 186–204 by Chengyu Shi et al. for details.