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Interactions between meltwater flow and ice shelf basal channels are studied using a 3D boundary current model. Deep channels are found to significantly enhance channelized basal melting, meltwater channeling, and warming and salinization of channel flow.

The intrusion of relatively warm water is causing the recent rapid thinning of the Dotson ice shelf, West Antarctica. Here, the authors analyzed two-years of mooring data from the Dotson ice shelf front and found that seasonal variability of the ocean circulation and ocean surface stress are the main causes of variability in heat transport.

Thinning ice in West Antarctica is currently contributing about 10% of the observed rise in global sea level. Observations obtained from an autonomous underwater vehicle operating beneath Pine Island Glacier, West Antarctica, reveal that the glacier was recently grounded on a transverse ridge in the sea floor, but now warm sea water flows through the widening gap above the ridge.

Whole-genome sequencing is used to analyse the landscape of somatic mutation in intestinal crypts from 16 mammalian species, revealing that rates of somatic mutation inversely scale with the lifespan of the animal across species.

Many RNAs become functional before their synthesis completes. Here the authors employ a single-molecule vectorial folding assay mimicking RNA transcription and show that the ZTP riboswitch is kinetically controlled and activated by slower unwinding and strategic pausing.

Body size reduction in mammals is accompanied by only a moderate reduction in brain size, so that the brains of dwarfs are proportionately larger than those of giants. Here, the brains of extinct dwarf hippos from the island of Madagascar are shown to be disproportionately very much smaller than those of their closest mainland relatives. If this trend no longer holds true on islands, it may explain the exceptionally small brain size of the diminutive hominin, Homo floresiensis.

It has been suggested that Antarctic ice sheets can become unstable and undergo irreversible retreat, but so far observational evidence for this mechanism is missing. Here, the authors show evidence that such an irreversible retreat occurred at Pine Island Glacier in West Antarctica in the 1970s.

The ice shelf buttressing Antarctica’s Pine Island Glacier has been melting rapidly. Observations taken between 1994 and 2009 show that meltwater production has increased by about 50% since 1994, as a result of a stronger circulation below the ice shelf.

Subglacial meltwater channels beneath the Antarctic Ice Sheet have been reported, but the nature and distribution of these meltwater pathways are unclear. Remote sensing observations reveal persistent channelized features beneath the Filchner–Ronne Ice Shelf in West Antarctica, suggesting widespread channelized flow driven by melting.

The spindle assembly checkpoint (SAC) safeguards chromosome segregation by regulating the anaphase promoting complex/cyclosome (APC/C), allowing chromosomes to correctly attach to mitotic spindles. Here the authors reveal a role for Cullin–RING ubiquitin ligase complex 4 (CRL4) in regulating metaphase to anaphase transition via BUB3 degradation.

The GEMINI consortium sequenced 1,000 cases of idiopathic male infertility and identified a plausible Mendelian cause in 20% of cases. The infertility genes can be grouped by expression pattern, facilitating their interpretation and follow-up.

The ‘plane of satellite galaxies’ surrounding our Milky Way seemed to defy dark matter theory for 40 years. Observations now suggest that the alignment is transient, while new simulations form similar structures far more often than previously thought.

Pertussis toxin is used extensively for perturbing Gαi/o pathways in the study of physiology and disease, but an equivalent inhibitor of Gαq signalling is not currently available to the research community. Here the authors characterize FR900359 as a specific Gq inhibitor and demonstrate its utility to dissect GPCR signalling and its potential to inhibit melanoma cells.

Pine Island Glacier terminates in a rapidly melting ice shelf and ocean conditions are believed to influence its contribution to sea level rise. Here, the authors show that variability in these ocean conditions is driven by a combination of changes in ocean circulation and local surface heat fluxes.

Glacial melt can modify heat transport, and therefore ocean processes, associated with ice front retreat, as revealed by direct observations from the Pine Island Bay region of Antarctica.

New simulations find that one of Antarctica’s largest ice shelves, the Filchner–Ronne, may be less vulnerable to climate change than previously thought. Melting of the ice shelf initially decreases for many decades, and only increases when global warming exceeds approximately 7 °C.

Episodic melting of some Antarctic ice shelves is linked to ocean temperature cycles, according to new observations collected over 17 years near the Dotson Ice Shelf.

Catalytic mechanisms of enzymes are well understood, but achieving diverse reaction chemistries in re-engineered proteins can be difficult. Here the authors show a highly efficient and thermostable artificial enzyme that catalyzes a diverse array of substrate oxidations coupled to the reduction of H₂O₂.

Anthropogenic changes in Antarctic shelf-break winds from the 1920s onwards have contributed to ice loss in the Amundsen Sea, along with natural variability, suggests an analysis of observations and model simulations.

The micronutrients iron and manganese are enriched in the Southern Ocean eastern Pacific sector at 2 to 4 km depth, probably from hydrothermal activity at ocean ridges, as revealed in depth profiles, and they could reach the surface mixed layer within two decades according to simulated water trajectories.

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Chromodomain Helicase DNA-binding (CHD) proteins have been implicated in neurodevelopmental processes. Here, the authors identify missense variants in CHD3 that disturb its chromatin remodeling activities and cause a neurodevelopmental disorder with macrocephaly and speech and language impairment.

Whole-exome analysis of individuals with developmental disorders shows that de novo mutations can equally cause loss or altered protein function, but that most mutations causing altered protein function have not yet been described.

Simon Stacey, Kari Stefansson and colleagues show that a germline variant in the TP53 polyadenylation signal is associated with increased risk of basal cell carcinoma and other solid tumors.

Stephen Wright, Detlef Weigel and colleagues report the whole-genome sequence of Capsella rubella, a highly selfing crucifer found throughout much of southern and western Europe. They compare mixed-stage flower bud transcriptomes from C. rubella and C. grandiflora, finding a shift in expression of genes associated with flowering phenotypes and providing insights into the transition to selfing.

The mechanism producing Antarctic meltwater at depth is elucidated and modelled.

Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.