Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–6 of 6 results
Advanced filters: Author: Anders Fuglsang Clear advanced filters

  • The Class 2 family of CRISPR nucleases named Cas12j, which shares only low sequence identity with other CRISPR nucleases was recently identified in the biggiephage clade of phages. Here, the authors present the cryo-EM structure of a functional Cas12j3−crRNA complex in the post-catalytic state and discuss Cas12j3 PAM recognition, hybrid stabilisation and the activation mechanism.

    • Arturo Carabias
    • Anders Fuglsang
    • Guillermo Montoya
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • In type I-D CRISPR–Cas systems, the nuclease and helicase activities are carried out by separate subunits. The crystal structure of Sulfolobus islandicus type I-D large subunit Cas10d, containing a nuclease ___domain, reveals unusual architecture. The structure of Cas10d in complex with anti-CRISPR protein AcrID1 suggests that the latter sequesters Cas10d in a nonfunctional state.

    • M. Cemre Manav
    • Lan B. Van
    • Ditlev E. Brodersen
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Establishing the relative transmissibility of emerging variants of SARS-CoV-2 is key for pandemic management. Here, the authors use full-population administrative data from Denmark linked to PCR test results and estimate that the Alpha variant was ~60% higher than other strains circulating in early 2021.

    • Frederik Plesner Lyngse
    • KÃ¥re Mølbak
    • Carsten Thure Kirkeby
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-8