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Improving gene isoform quantification with miniQuant

Gene isoforms are quantified with a machine learning method that optimally integrates long and short sequencing reads.

Haoran Li
Dingjie Wang
Kin Fai Au
ResearchOpen Access03 Jun 2025
Nature Biotechnology

P: 1-13
Publisher Correction: Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming

Andrea Cipriano
Mahdi Moqri
Vittorio Sebastiano
Amendments and Corrections04 Jan 2024
Nature Aging

Volume: 4, P: 275
PRC2-AgeIndex as a universal biomarker of aging and rejuvenation

DNA methylation (DNAm) is a key biomarker of aging, with age-related DNAm changes being well-characterized. Here, the authors show that low-methylated regions (LMRs) bound by PRC2 in embryonic stem cells gain methylation with age in somatic cells, proposing the “PRC2-AgeIndex” as a universal biomarker of cellular aging.

Mahdi Moqri
Andrea Cipriano
Vittorio Sebastiano
ResearchOpen Access16 Jul 2024
Nature Communications

Volume: 15, P: 1-12
Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming

Cipriano et al. review recent progress in using epigenetic reprogramming to combat age-related deterioration at the cellular, tissue and organismal level, discussing reprogramming strategies and mechanisms, as well as remaining challenges in the field.

Andrea Cipriano
Mahdi Moqri
Vittorio Sebastiano
Reviews15 Dec 2023
Nature Aging

Volume: 4, P: 14-26
Monolayer platform to generate and purify primordial germ-like cells in vitro provides insights into human germline specification

Generation of primordial germ cell-like cells (PGCLCs) from human pluripotent cells (hPSCs) offers insight into the mechanisms underlying human reproduction, but often requires complex methods. Here they describe a simplified monolayer protocol to differentiate and purify PGCLCs for further analysis.

Sivakamasundari Vijayakumar
Roberta Sala
Vittorio Sebastiano
ResearchOpen Access14 Sept 2023
Nature Communications

Volume: 14, P: 1-19
Observation of the rare B_s⁰ →µ⁺µ⁻ decay from the combined analysis of CMS and LHCb data

Combined analysis of proton-proton collision data from the Large Hadron Collider at CERN by the CMS and LHCb collaborations leads to the observation of the extremely rare decay of the strange B meson into muons; the result is compatible with the standard model of particle physics, and does not show any signs of new physics, such as supersymmetry.

V. Khachatryan
A.M. Sirunyan
E. Pesen
ResearchOpen Access13 May 2015
Nature

Volume: 522, P: 68-72
HOTAIRM1 regulates neuronal differentiation by modulating NEUROGENIN 2 and the downstream neurogenic cascade

Jessica Rea
Valentina Menci
Elisa Caffarelli
ResearchOpen Access13 Jul 2020
Cell Death & Disease

Volume: 11, P: 1-15
Metabolic response to amylose-rich wheat-based rusks in overweight individuals

Claudia Vetrani
Francesco Sestili
Gabriele Riccardi
Research13 Mar 2018
European Journal of Clinical Nutrition

Volume: 72, P: 904-912
Tick microbiome and pathogen acquisition altered by host blood meal

Andrea Swei
Jessica Y Kwan
Research18 Nov 2016
The ISME Journal

Volume: 11, P: 813-816
Peripheral Blood Immune Response Elicited by Beta-Lactoglobulin in Childhood Cow's Milk Allergy

Immacolata Vocca
Roberto Berni Canani
Carmen Gianfrani
Research01 Dec 2011
Pediatric Research

Volume: 70, P: 549-554

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