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Repeated blood–brain barrier opening with a nine-emitter implantable ultrasound device in combination with carboplatin in recurrent glioblastoma: a phase I/II clinical trial

Recent work indicates that drug delivery to the brain can be improved through disruption of the blood brain barrier using low intensity pulsed ultrasound. Here, the authors report a phase I/II clinical trial investigating the combination of a nine-emitter implantable ultrasound device and carboplatin in patients with recurrent glioblastoma.

Alexandre Carpentier
Roger Stupp
Ahmed Idbaih
ResearchOpen Access23 Feb 2024
Nature Communications

Volume: 15, P: 1-12
Non-canonical NOTCH3 signalling limits tumour angiogenesis

Notch signalling is deregulated in several cancers; therefore, strategies targeting this pathway are currently being explored. Here the authors report a pro-apoptotic function of Notch3 in endothelial cells; consequently, when Notch3 is silenced in stroma cells, tumour growth and angiogenesis are increased.

Shuheng Lin
Ana Negulescu
Patrick Mehlen
ResearchOpen Access18 Jul 2017
Nature Communications

Volume: 8, P: 1-12
Reduced venetoclax exposure to 7 days vs standard exposure with hypomethylating agents in newly diagnosed AML patients

Christophe Willekens
Alexandre Bazinet
Courtney DiNardo
ResearchOpen Access17 Apr 2025
Blood Cancer Journal

Volume: 15, P: 1-8
The activation trajectory of plasmacytoid dendritic cells in vivo during a viral infection

Plasmacytoid dendritic cells (pDCs) are a major source of type I interferon (IFN-I). Dalod and colleagues show that IFN-I production and T cell activation were performed by the same pDC, but these occurred sequentially and in different micro-anatomical locations during virus infection.

Abdenour Abbas
Thien-Phong Vu Manh
Elena Tomasello
Research20 Jul 2020
Nature Immunology

Volume: 21, P: 983-997
Quantum breakdown of superconductivity in low-dimensional materials

The breakdown of superconductivity is described as a reduction in the amplitude of the order parameter or a breakdown in phase coherence of Cooper pairs. This Review Article highlights recent results that show both mechanisms may be at play simultaneously.

Benjamin Sacépé
Mikhail Feigel’man
Teunis M. Klapwijk
Reviews07 Jul 2020
Nature Physics

Volume: 16, P: 734-746
Post-translational insertion of boron in proteins to probe and modulate function

Post-translational site-selective formation of boronoalanine in proteins enables applications of boron for binding partner capture, footprinting of interactions with reactive oxygen species, proteolytic control and mapping of transient structures.

Tim A. Mollner
Patrick G. Isenegger
Benjamin G. Davis
ResearchOpen Access01 Nov 2021
Nature Chemical Biology

Volume: 17, P: 1245-1261
Intratubular amyloid in light chain cast nephropathy is a risk factor for systemic light chain amyloidosis

Jean-Baptiste Gibier
Viviane Gnemmi
David Buob
Research20 Oct 2017
Modern Pathology

Volume: 31, P: 452-462

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Repeated blood–brain barrier opening with a nine-emitter implantable ultrasound device in combination with carboplatin in recurrent glioblastoma: a phase I/II clinical trial

Non-canonical NOTCH3 signalling limits tumour angiogenesis

Reduced venetoclax exposure to 7 days vs standard exposure with hypomethylating agents in newly diagnosed AML patients

The activation trajectory of plasmacytoid dendritic cells in vivo during a viral infection

Quantum breakdown of superconductivity in low-dimensional materials

Post-translational insertion of boron in proteins to probe and modulate function

Intratubular amyloid in light chain cast nephropathy is a risk factor for systemic light chain amyloidosis

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