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Showing 1–8 of 8 results
Advanced filters: Author: Benjamin R Sabari Clear advanced filters

  • Transcriptional condensates, which are formed through dynamic multivalent interactions between proteins, RNA and chromatin, regulate transcription by compartmentalizing its machinery in the crowded nuclear environment. These condensates regulate animal and plant development, cell signalling and responses to the environment, and they are dysregulated in developmental disorders, cancer and neurodegeneration.

    • Gaofeng Pei
    • Heankel Lyons
    • Benjamin R. Sabari
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 26, P: 213-236

  • Biomolecular condensates are membraneless cellular compartments that concentrate molecules such as proteins and nucleic acids. In this Review, the authors discuss how complementation experiments, a classic genetics approach, have provided valuable insights into the functions of biomolecular condensates.

    • Benjamin R. Sabari
    • Anthony A. Hyman
    • Denes Hnisz
    Reviews
    Nature Reviews Genetics
    Volume: 26, P: 279-290

  • In addition to acetylation, eight types of structurally and functionally different short-chain acylations have recently been identified as important histone Lys modifications: propionylation, butyrylation, 2-hydroxyisobutyrylation, succinylation, malonylation, glutarylation, crotonylation and β-hydroxybutyrylation. These modifications are regulated by enzymatic and metabolic mechanisms and have physiological functions, which include signal-dependent gene activation and metabolic stress.

    • Benjamin R. Sabari
    • Di Zhang
    • Yingming Zhao
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 90-101

  • Histone post-translational modifications are important regulators of chromatin structure and gene expression. Lysine 2-hydroxisobutyrylation sites, discovered by MS and validated by chemical synthesis, are found in active chromatin and associated with male germ cell differentiation.

    • Lunzhi Dai
    • Chao Peng
    • Yingming Zhao
    Research
    Nature Chemical Biology
    Volume: 10, P: 365-370

  • Many fusion oncoproteins (FOs) form condensates, some form in the nucleus and regulate gene expression while others form in the cytoplasm and promote cell signaling. In this work, the authors report the analysis of physicochemical features to enable prediction of FO condensation behavior.

    • Swarnendu Tripathi
    • Hazheen K. Shirnekhi
    • Richard W. Kriwacki
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-25

  • RNA polymerase II with a hypophosphorylated C-terminal ___domain preferentially incorporates into mediator condensates, and with a hyperphosphorylated C-terminal ___domain into splicing-factor condensates, revealing phosphorylation as a regulatory mechanism in condensate preference.

    • Yang Eric Guo
    • John C. Manteiga
    • Richard A. Young
    Research
    Nature
    Volume: 572, P: 543-548

  • For three decades, the treatment of small-cell lung cancer (SCLC) has remained essentially unchanged, and patient outcomes remain dismal. In the past 5 years, however, advances in our understanding of the disease, at the molecular level, have resulted in the development of new therapeutic strategies, encompassing immunotherapies and novel molecularly targeted agents. Herein, authors review the breakthroughs that hold the promise to improve SCLC outcomes.

    • Joshua K. Sabari
    • Benjamin H. Lok
    • Charles M. Rudin
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 14, P: 549-561