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Advanced filters: Author: Boris Kantor Clear advanced filters

  • Adeno-associated vectors (AAVs) are frequently used for the delivery of genetic cargo but their small packaging capacity is not suitable for delivery of large constructs, including most CRISPR/dCas9-effector systems. Here the authors report a compact dCas9-based repressor system packaged within a single, optimized AAV vector.

    • Boris Kantor
    • Bernadette O’Donovan
    • Ornit Chiba-Falek
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15