In this Resource, the authors generate a genome-wide methylation profile of DNA from the normal-appearing white matter of control and multiple sclerosis–affected brains and find subtle, but widely distributed, differences. In particular, they report that hypermethylated genes that regulate oligodendrocyte survival are also transcriptionally downregulated.
- Jimmy L Huynh
- Paras Garg
- Patrizia Casaccia
