Nature Search

The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures

Epileptic brains display inhibitory restraint as manifested by the spread of synchronized activities being delayed in timing. Here, Elliot Smith and colleagues show fast-moving traveling wave that originates from the edge of ictal wavefront with subsequent depolarization and multiunit firing in the seizing brain regions in epileptic patients.

Elliot H. Smith
Jyun-you Liou
Catherine A. Schevon
ResearchOpen Access29 Mar 2016
Nature Communications

Volume: 7, P: 1-12
Evidence of an inhibitory restraint of seizure activity in humans

Seizure activity in the brain is characterized by the recruitment of cortical neuronal activity. Schevon and colleagues study seizure activity in human subjects and find that the recruitment of neurons is hypersynchronous and that there is an intrinsic restraint on the propagation of this activity.

Catherine A. Schevon
Shennan A. Weiss
Andrew J. Trevelyan
ResearchOpen Access11 Sept 2012
Nature Communications

Volume: 3, P: 1-11
Sleep spindles as a predictor of cognitive motor dissociation and recovery of consciousness after acute brain injury

In acutely brain injured patients, well-formed sleep spindles on EEG were more likely present in patients with cognitive motor dissociation, were associated with a shorter time to recovery of consciousness and predicted recovery of independence.

Elizabeth E. Carroll
Qi Shen
Jan Claassen
Research03 Mar 2025
Nature Medicine

Volume: 31, P: 1578-1585
Multiscale temporal integration organizes hierarchical computation in human auditory cortex

Norman-Haignere et al. present a general method for estimating neural integration windows. Applied to human intracranial recordings, the method reveals how human auditory cortex integrates across the multiscale temporal structure of natural sounds.

Sam V. Norman-Haignere
Laura K. Long
Nima Mesgarani
Research10 Feb 2022
Nature Human Behaviour

Volume: 6, P: 455-469
Functionally distinct high and low theta oscillations in the human hippocampus

We show that the human hippocampus exhibits two distinct theta oscillations during spatial navigation with the faster oscillation in posterior regions showing movement modulation. This result suggests a distinct feature of the human hippocampus compared to rodents, which generally show a single 8 Hz rhythm.

Abhinav Goyal
Jonathan Miller
Joshua Jacobs
ResearchOpen Access18 May 2020
Nature Communications

Volume: 11, P: 1-10
Memory retrieval modulates spatial tuning of single neurons in the human entorhinal cortex

Qasim et al. describe neurons in the human entorhinal cortex that activate near the locations in space that a person is cued to recall during a memory task. These results show one way in which the cognitive map shifts according to memory demands.

Salman E. Qasim
Jonathan Miller
Joshua Jacobs
Research11 Nov 2019
Nature Neuroscience

Volume: 22, P: 2078-2086
Widespread temporal coding of cognitive control in the human prefrontal cortex

Using intracranial recordings in humans, the authors found decision conflict-related effects on firing rate in the dorsal anterior cingulate cortex (dACC), on spike-phase coupling in the dACC, and on spike-field coherence in the dorsolateral prefrontal cortex.

Elliot H. Smith
Guillermo Horga
Sameer A. Sheth
Research30 Sept 2019
Nature Neuroscience

Volume: 22, P: 1883-1891
Lateralized hippocampal oscillations underlie distinct aspects of human spatial memory and navigation

Theta oscillations are implicated in memory formation. Here, the authors show that low-theta oscillations in the hippocampus are differentially modulated between each hemisphere, with oscillations in the left increasing when successfully learning object–___location pairs and in the right during spatial navigation.

Jonathan Miller
Andrew J. Watrous
Joshua Jacobs
ResearchOpen Access21 Jun 2018
Nature Communications

Volume: 9, P: 1-12
Spatiotemporal spike-centered averaging reveals symmetry of temporal and spatial components of the spike-LFP relationship during human focal seizures

Spatiotemporal spike-centered averaging (st-SCA) allows for the visualization of spike-local field potential relationships across both temporal and spatial domains from microelectrode array recordings.

Somin Lee
Sarita S. Deshpande
Wim van Drongelen
ResearchOpen Access25 Mar 2023
Communications Biology

Volume: 6, P: 1-12
Dual mechanisms of ictal high frequency oscillations in human rhythmic onset seizures

Elliot H. Smith
Edward M. Merricks
Catherine A. Schevon
ResearchOpen Access05 Nov 2020
Scientific Reports

Volume: 10, P: 1-14

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