Nature Search

Measurement of SARS-CoV-2 RNA in wastewater tracks community infection dynamics

Testing sewage for the novel coronavirus reveals epidemiological trends.

Jordan Peccia
Alessandro Zulli
Saad B. Omer
Research18 Sept 2020
Nature Biotechnology

Volume: 38, P: 1164-1167
A reference map of potential determinants for the human serum metabolome

The levels of 1,251 metabolites are measured in 475 phenotyped individuals, and machine-learning algorithms reveal that diet and the microbiome are the determinants with the strongest predictive power for the levels of these metabolites.

Noam Bar
Tal Korem
Eran Segal
Research11 Nov 2020
Nature

Volume: 588, P: 135-140
Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias

Selvakumar, Clayton et al. use a porcine model of myocardial infarction and PSC-CM transplantation and identify atrial and pacemaker-like cardiomyocytes as the cause of engraftment arrhythmias and surface marker signatures to distinguish between arrhythmogenic and non-arrhythmogenic cardiomyocytes.

Dinesh Selvakumar
Zoe E. Clayton
James J. H. Chong
ResearchOpen Access06 Feb 2024
Nature Cardiovascular Research

Volume: 3, P: 145-165
Membrane augmentation in freezing tolerance of plant cells

J. SINGH
I. A. DE LA ROCHE
D. SIMINOVITCH
Research23 Oct 1975
Nature

Volume: 257, P: 669-670
Linking the Family of D₂ Receptors to Neuronal Circuits in Human Brain: Insights into Schizophrenia

Jeffrey N Joyce
James H Meador-Woodruff
Reviews01 Jun 1997
Neuropsychopharmacology

Volume: 16, P: 375-384
Genetic architecture of subcortical brain structures in 38,851 individuals

Genome-wide analysis identifies variants associated with the volume of seven different subcortical brain regions defined by magnetic resonance imaging. Implicated genes are involved in neurodevelopmental and synaptic signaling pathways.

Claudia L. Satizabal
Hieab H. H. Adams
M. Arfan Ikram
Research21 Oct 2019
Nature Genetics

Volume: 51, P: 1624-1636
Targeted isolation of Methanobrevibacter strains from fecal samples expands the cultivated human archaeome

Here, the authors present a new method for isolating methanogenic archaea from human fecal samples and establish stable archaeal cultures yielding nine previously uncultivated strains, which upon further genomic and functional analyzes suggest may be potentially associated with gastrointestinal diseases.

Stefanie Duller
Simone Vrbancic
Christine Moissl-Eichinger
ResearchOpen Access31 Aug 2024
Nature Communications

Volume: 15, P: 1-16
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

This study uses gene expression predictors for the dorsolateral prefrontal cortex and other brain regions to perform a transcriptomic imputation analysis of schizophrenia, identifying 413 genic associations across 13 brain regions and 36 significantly enriched pathways.

Laura M. Huckins
Amanda Dobbyn
Eli A. Stahl
Research25 Mar 2019
Nature Genetics

Volume: 51, P: 659-674
Somatic mosaicism reveals clonal distributions of neocortical development

A comprehensive analysis of brain somatic mosaicism across the neocortex demonstrates the origins and distribution patterns of cells within the human brain.

Martin W. Breuss
Xiaoxu Yang
Joseph G. Gleeson
Research20 Apr 2022
Nature

Volume: 604, P: 689-696
Multiparametric corticofugal modulation and plasticity in the auditory system

Nobuo Suga
Xiaofeng Ma
Reviews01 Oct 2003
Nature Reviews Neuroscience

Volume: 4, P: 783-794
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Cognitive function is associated with health and important life outcomes. Here, the authors perform a genome-wide association study for general cognitive function in 300,486 individuals and identify genetic loci that implicate neural and cell developmental pathways in this trait.

Gail Davies
Max Lam
Ian J. Deary
ResearchOpen Access29 May 2018
Nature Communications

Volume: 9, P: 1-16
Effect of Antipsychotics on Regional Cerebral Blood Flow Measured with Positron Emission Tomography

Del D Miller
Nancy C Andreasen
Richard D Hichwa
Research01 Oct 1997
Neuropsychopharmacology

Volume: 17, P: 230-240
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence

P J Harrison
D R Weinberger
Reviews20 Jul 2004
Molecular Psychiatry

Volume: 10, P: 40-68
Molecular landscapes of human hippocampal immature neurons across lifespan

Single-nucleus RNA-sequencing analysis supports the presence of immature dentate granule cells throughout the human lifespan and shows that these cells are reduced in number and dysregulated in Alzheimer's disease.

Yi Zhou
Yijing Su
Hongjun Song
Research06 Jul 2022
Nature

Volume: 607, P: 527-533
Temporal Lobe Metabolic Differences in Medication-Free Outpatients with Schizophrenia via the PET-600

Thomas E Nordahl
Natalia Kusubov
Thomas F Budinger
Research01 Dec 1996
Neuropsychopharmacology

Volume: 15, P: 541-554
Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product

Jan Sap
Alberto Muñoz
Björn Vennström
Research20 Jul 1989
Nature

Volume: 340, P: 242-244
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

Barbara Franke
Jason L Stein
Patrick F Sullivan
Research01 Feb 2016
Nature Neuroscience

Volume: 19, P: 420-431
Structural variation in the gut microbiome associates with host health

The authors systematically characterize structural variation in the genomes of gut microbiota and show that they are associated with bacterial fitness and with host risk factors, and that examining genes coded in these regions facilitates investigation of mechanisms that may underlie these associations.

David Zeevi
Tal Korem
Eran Segal
Research27 Mar 2019
Nature

Volume: 568, P: 43-48
Psychobiologic Correlates of Treatment Response in Schizophrenia

Jeffrey A Lieberman
Jose Ma Alvir
Margaret Woerner
Research01 Mar 1996
Neuropsychopharmacology

Volume: 14, P: 13-21
The Neuropsychopharmacology of Phencyclidine: From NMDA Receptor Hypofunction to the Dopamine Hypothesis of Schizophrenia

J David Jentsch
Robert H Roth
Reviews01 Mar 1999
Neuropsychopharmacology

Volume: 20, P: 201-225
Effects of Olanzapine on Regional C-Fos Expression in Rat Forebrain

George S Robertson
H Christian Fibiger
Research01 Feb 1996
Neuropsychopharmacology

Volume: 14, P: 105-110
Convergence of placenta biology and genetic risk for schizophrenia

Early-life complications modulate the association of genomic risk and schizophrenia.

Gianluca Ursini
Giovanna Punzi
Daniel R. Weinberger
Research28 May 2018
Nature Medicine

Volume: 24, P: 792-801
Butler enables rapid cloud-based analysis of thousands of human genomes

Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.

Sergei Yakneen
Sebastian M. Waszak
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Biotechnology

Volume: 38, P: 288-292
Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population

P A Thomson
N R Wray
D J Porteous
Research19 Apr 2005
Molecular Psychiatry

Volume: 10, P: 657-668
Novel genetic loci underlying human intracranial volume identified through genome-wide association

In a GWAS study of 32,438 adults, the authors discovered five novel loci for intracranial volume and confirmed two known signals. Variants for intracranial volume were also related to childhood and adult cognitive function and to Parkinson's disease, and enriched near genes involved in growth pathways, including PI3K-AKT signaling.

Hieab H H Adams
Derrek P Hibar
Paul M Thompson
Research03 Oct 2016
Nature Neuroscience

Volume: 19, P: 1569-1582
Developmental Regulation of the Dopamine D₁ Receptor in Human Caudate and Putamen

Deidra M Montague
Cindy P Lawler
John H Gilmore
Research01 Nov 1999
Neuropsychopharmacology

Volume: 21, P: 641-649
Distinct components of spatial learning revealed by prior training and NMDA receptor blockade

D. M. Bannerman
M. A. Good
R. G. M. Morris
Research09 Nov 1995
Nature

Volume: 378, P: 182-186
Differential Response to the Cholinergic Agonist Arecoline among Different Cognitive Modalities in Alzheimer’s Disease

Kathleen C Raffaele
Sanjay Asthana
Timothy T Soncrant
Research01 Aug 1996
Neuropsychopharmacology

Volume: 15, P: 163-170
Complement genes contribute sex-biased vulnerability in diverse disorders

Sexual dimorphism in genetic vulnerability to schizophrenia, systemic lupus erythematosus and Sjögren’s syndrome is linked to differential protein abundance from alleles of complement component 4.

Nolan Kamitaki
Aswin Sekar
Steven A. McCarroll
Research11 May 2020
Nature

Volume: 582, P: 577-581
Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk

The authors provide a comprehensive, single base resolution view of association between genetic variation and DNA methylation in human brain. They also show that heritability attributed to schizophrenia GWAS-associated variants reflects the epigenetic plasticity of the brain.

Kira A. Perzel Mandell
Nicholas J. Eagles
Andrew E. Jaffe
ResearchOpen Access02 Sept 2021
Nature Communications

Volume: 12, P: 1-12
Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development

This Brain Somatic Mosaicism Network analysis of 283 cases of malformations of cortical development identifies 69 candidate and known genes in 76 patients. Single-nucleus RNA sequencing and mouse modeling implicate radial glia and daughter excitatory neurons.

Changuk Chung
Xiaoxu Yang
Joseph G. Gleeson
Research12 Jan 2023
Nature Genetics

Volume: 55, P: 209-220
Novel genetic loci associated with hippocampal volume

The hippocampus in mammalian brain varies in size across individuals. Here, Hibar and colleagues perform a genome-wide association meta-analysis to find six genetic loci with significant association to hippocampus volume.

Derrek P. Hibar
Hieab H. H. Adams
M. Arfan Ikram
ResearchOpen Access18 Jan 2017
Nature Communications

Volume: 8, P: 1-12
Identification of bacteria-derived HLA-bound peptides in melanoma

HLA peptidomic analysis identifies recurrent intracellular bacteria-derived peptides presented on HLA-I and HLA-II molecules in melanoma tumours, revealing how bacteria can modulate immune functions and responses to cancer therapies.

Shelly Kalaora
Adi Nagler
Yardena Samuels
Research17 Mar 2021
Nature

Volume: 592, P: 138-143
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions from a GWAS meta-analysis in 22,824 adults.

Edith Hofer
Gennady V. Roshchupkin
Sudha Seshadri
ResearchOpen Access22 Sept 2020
Nature Communications

Volume: 11, P: 1-16
A comparison of the effect of hyaluronic acid versus gentamicin on corneal epithelial healing

H Stiebel-Kalish
D D Gaton
A Solomon
Research01 Sept 1998
Eye

Volume: 12, P: 829-833
How Many Microbes Really Constitute Environmental Release?

Harlee S. Strauss
Research01 Mar 1987
Bio/Technology

Volume: 5, P: 232-237
The unprecedented Pacific Northwest heatwave of June 2021

The 2021 unprecedented Pacific Northwest heatwave broke temperature records by extraordinary amounts. Impacts included hundreds of deaths, mass-mortalities of marine life, increased wildfires, reduced crop and fruit yields, and river flooding.

Rachel H. White
Sam Anderson
Greg West
ResearchOpen Access09 Feb 2023
Nature Communications

Volume: 14, P: 1-20
Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk

Jaffe et al. profile the granule cell layer of the human hippocampus and find unique molecular associations for aging and genetic variation, as well as diagnosis with schizophrenia and its genetic risk, that were previously undiscovered in homogenate tissue.

Andrew E. Jaffe
Daniel J. Hoeppner
Thomas M. Hyde
Research16 Mar 2020
Nature Neuroscience

Volume: 23, P: 510-519
A Randomized trial assessing Efficacy and safety of Mineralocorticoid receptor Antagonist therapy compared to Standard antihypertensive Therapy in hypErtension with low Renin (REMASTER): rationale and study design

Sonali S. Shah
Stella May Gwini
Jun Yang
ResearchOpen Access18 Jul 2024
Journal of Human Hypertension

Volume: 38, P: 663-668
Comprehensive molecular characterization of mitochondrial genomes in human cancers

Analysis of mitochondrial genomes (mtDNA) by using whole-genome sequencing data from 2,658 cancer samples across 38 cancer types identifies hypermutated mtDNA cases, frequent somatic nuclear transfer of mtDNA and high variability of mtDNA copy number in many cancers.

Yuan Yuan
Young Seok Ju
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 342-352
Regulation of Ionotropic Glutamate Receptors in the Rat Brain in Response to the Atypical Antipsychotic Seroquel (Quetiapine Fumarate)

F Tascedda
E Lovati
MA Riva
Research01 Aug 1999
Neuropsychopharmacology

Volume: 21, P: 211-217
Schizophrenia genes within cortical neural circuits

P J Harrison
D R Weinberger
Research17 Dec 2004
Molecular Psychiatry

Volume: 10, P: 5
Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs

Here, authors present results of a hiPSC transcriptomics study on corticogenesis from multiple donors across four transitions in differentiation. They present a bulk data deconvolution method and show that co-culturing human NPCs with rodent astrocytes results in mutually synergistic maturation.

Emily E. Burke
Joshua G. Chenoweth
Andrew E. Jaffe
ResearchOpen Access23 Jan 2020
Nature Communications

Volume: 11, P: 1-14
Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

Analysis of whole-genome sequencing data across 2,658 tumors spanning 38 cancer types shows that chromothripsis is pervasive, with a frequency of more than 50% in several cancer types, contributing to oncogene amplification, gene inactivation and cancer genome evolution.

Isidro Cortés-Ciriano
Jake June-Koo Lee
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 331-341
Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex

DNA methylation in human brain shows dramatic variation across development. Genetic loci implicated in risk for schizophrenia are enriched for epigenetic states that show changes from the transition from prenatal to postnatal life. These findings suggest that early development is involved in both genetic and environmental risk factors for schizophrenia.

Andrew E Jaffe
Yuan Gao
Joel E Kleinman
Research30 Nov 2015
Nature Neuroscience

Volume: 19, P: 40-47
Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition

The usage of specific distal regulatory regions within the genome is critical for fate specification and cell maturation. Here, the authors show that the accumulation of the oncoprotein SET, as occurring in the rare Schinzel-Giedion syndrome, and associated histone hypo-acetylation interfere with normal enhancer repertoire employed during brain development.

Mattia Zaghi
Federica Banfi
Alessandro Sessa
ResearchOpen Access03 Jun 2023
Nature Communications

Volume: 14, P: 1-21
Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation

Arterial macrophages develop from either yolk sac or bone marrow progenitors. Here, the author show that ageing-induced reduction of arterial macrophages is not replenished by bone marrow-derived cells, but under inflammatory conditions circulating monocytes are recruited to maintain homeostasis, while arterial macrophages of yolk sac origin carry out tissue repair.

Tobias Weinberger
Dena Esfandyari
Christian Schulz
ResearchOpen Access11 Sept 2020
Nature Communications

Volume: 11, P: 1-16
Environment dominates over host genetics in shaping human gut microbiota

Statistical analyses of a metagenomics-sequenced human cohort identify a relatively minor role for genetics in determining microbiome composition and show that several human phenotypes are as strongly associated with the gut microbiome as with host genetics.

Daphna Rothschild
Omer Weissbrod
Eran Segal
Research28 Feb 2018
Nature

Volume: 555, P: 210-215
Electrical Stimulation of the Medial Prefrontal Cortex Increases Dopamine Release in the Striatum

Matthew T. Taber
Hans C. Fibiger
Research01 Dec 1993
Neuropsychopharmacology

Volume: 9, P: 271-275
Spatio-temporal transcriptome of the human brain

Hyo Jung Kang
Yuka Imamura Kawasawa
Nenad Šestan
Research26 Oct 2011
Nature

Volume: 478, P: 483-489

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