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Showing 1–7 of 7 results
Advanced filters: Author: David Owald Clear advanced filters

  • A state-dependent dopamine filter system in the male Drosophila brain balances threat perception against the drive to mate.

    • Laurie Cazalé-Debat
    • Lisa Scheunemann
    • Carolina Rezaval
    ResearchOpen Access
    Nature
    Volume: 634, P: 635-643

  • The Drosophila proteins Neuroligin (Nlg1) and Neurexin (Nrx-1) form a trans-synaptic complex that regulates synapse formation at the neuromuscular junction. Here the authors show that Syd-1, also known to regulate active zone formation, interacts with presynaptic Nrx-1, promoting synaptic clustering and immobilization of Nrx-1, and subsequent glutamate receptor incorporation.

    • David Owald
    • Omid Khorramshahi
    • Stephan J Sigrist
    Research
    Nature Neuroscience
    Volume: 15, P: 1219-1226

  • Synaptic plasticity ensures functionality during perturbations and enables memory formation. Here, the authors describe homeostatic functional and nano-modular active zone modifications for immediate and long-lasting enhancement of neurotransmitter release, and identify Unc13 as a presynaptic molecular target for homeostatic potentiation and learning.

    • Mathias A. Böhme
    • Anthony W. McCarthy
    • Alexander M. Walter
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • To date, no Ca2 + -selective channelrhodopsins have been characterized. In this study, Fernandez Lahore et al. report two calcium-permeable channelrhodopsins (CapChR1 and 2) for the photocontrol of calcium signalling in excitable tissue.

    • Rodrigo G. Fernandez Lahore
    • Niccolò P. Pampaloni
    • Peter Hegemann
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • Using the Drosophila system, this study shows that rewarding and motivational properties of water are mediated by different subsets of dopaminergic neurons. The study also shows a satiety state–dependent effect in which thirst can change water avoidance behavior into water-seeking behavior and demonstrates that water wanting versus liking versus learning are separable at the level of behavior and the underlying neural circuit.

    • Suewei Lin
    • David Owald
    • Scott Waddell
    Research
    Nature Neuroscience
    Volume: 17, P: 1536-1542

  • Dopamine is synonymous with reward in mammals but associated with aversive reinforcement in insects, where reward seems to be signalled by octopamine; here it is shown that flies have discrete populations of dopamine neurons representing positive or negative values that are coordinately regulated by octopamine.

    • Christopher J. Burke
    • Wolf Huetteroth
    • Scott Waddell
    Research
    Nature
    Volume: 492, P: 433-437