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Showing 1–3 of 3 results

Advanced filters: Author: Dustin C. Becht Clear advanced filters

A multivalent engagement of ENL with MOZ

Epigenetic coregulators ENL (eleven-nineteen-leukemia) and MOZ (monocytic leukemia zinc finger) are implicated in leukemias. Here, the authors report the acetylation-dependent and acetylation-independent mechanism for the ENL–MOZ complex formation and show the colocalization of ENL and MOZ at active promoters.

Dustin C. Becht
Karthik Selvam
Tatiana G. Kutateladze
Research10 Jan 2025
Nature Structural & Molecular Biology

Volume: 32, P: 709-718
MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix ___domain

Human acetyltransferases MOZ and MORF mediate development programs and are dysregulated in diseases. Here the authors identified two winged helix (WH) domains in MORF/MOZ and characterized their DNA binding functions, including targeting of CpG by WH1.

Dustin C. Becht
Brianna J. Klein
Tatiana G. Kutateladze
ResearchOpen Access08 Feb 2023
Nature Communications

Volume: 14, P: 1-20
Molecular insight into interactions between the Taf14, Yng1 and Sas3 subunits of the NuA3 complex

The yeast NuA3 complex regulates gene transcription and the cell cycle. Nguyen et al. show that intersubunit interactions involving the Taf14, Yng1 and Sas3 subunits are essential in biological activities of the NuA3 complex.

Minh Chau Nguyen
Hosein Rostamian
Tatiana G. Kutateladze
ResearchOpen Access24 Jun 2024
Nature Communications

Volume: 15, P: 1-11