Nature Search

Structured detection for simultaneous super-resolution and optical sectioning in laser scanning microscopy

A reconstruction method for image scanning microscopy exploits all the information encoded in the four-dimensional image scanning microscopy dataset to achieve optical sectioning and maintain super-resolution and high-signal-to-noise-ratio imaging.

Alessandro Zunino
Giacomo Garrè
Giuseppe Vicidomini
ResearchOpen Access05 Jun 2025
Nature Photonics

P: 1-10
Single-photon microscopy to study biomolecular condensates

The wide variety of cellular processes involving biomolecular condensation makes their quantification a challenging task. Here, the authors present an integrated platform based on single-photon microscopy to study complex biomolecular processes.

Eleonora Perego
Sabrina Zappone
Giuseppe Vicidomini
ResearchOpen Access12 Dec 2023
Nature Communications

Volume: 14, P: 1-14
4D Single-particle tracking with asynchronous read-out single-photon avalanche diode array detector

Here, the authors upgrade a confocal laser scanning microscope with a single-photon array detector, achieving 40 nm lateral and 60 nm axial localisation precision with 100 photons and a sub-millisecond temporal sampling for real-time single-particle tracking with fluorescence lifetime measurement.

Andrea Bucci
Giorgio Tortarolo
Giuseppe Vicidomini
ResearchOpen Access23 Jul 2024
Nature Communications

Volume: 15, P: 1-12
M⁶A reduction relieves FUS-associated ALS granules

In Amyotrophic Lateral Sclerosis (ALS), formation of cytoplasmic inclusions by mutant protein aggregation is observed. Here the authors show that these inclusions dissolve faster when m⁶A RNA modification is inhibited in ALS cellular models.

Gaia Di Timoteo
Andrea Giuliani
Irene Bozzoni
ResearchOpen Access12 Jun 2024
Nature Communications

Volume: 15, P: 1-13
The BrightEyes-TTM as an open-source time-tagging module for democratising single-photon microscopy

The authors developed an open-source, low-cost, multi-channel time-tagging module for fluorescence lifetime image scanning microscopy and correlation spectroscopy that can tag in parallel multiple single-photon events with 30 ps precision.

Alessandro Rossetta
Eli Slenders
Giuseppe Vicidomini
ResearchOpen Access01 Dec 2022
Nature Communications

Volume: 13, P: 1-14
A minimalist model to measure interactions between proteins and synaptic vesicles

Eleonora Perego
Sofiia Reshetniak
Sarah Köster
ResearchOpen Access03 Dec 2020
Scientific Reports

Volume: 10, P: 1-13
BRAIN - Holocene archaeo-data for assessing plant-cultural diversity in Italy and other Mediterranean regions

Anna Maria Mercuri
Eleonora Clò
Assunta Florenzano
ResearchOpen Access22 May 2024
Scientific Data

Volume: 11, P: 1-11

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Structured detection for simultaneous super-resolution and optical sectioning in laser scanning microscopy

Single-photon microscopy to study biomolecular condensates

4D Single-particle tracking with asynchronous read-out single-photon avalanche diode array detector

M6A reduction relieves FUS-associated ALS granules

The BrightEyes-TTM as an open-source time-tagging module for democratising single-photon microscopy

A minimalist model to measure interactions between proteins and synaptic vesicles

BRAIN - Holocene archaeo-data for assessing plant-cultural diversity in Italy and other Mediterranean regions

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M⁶A reduction relieves FUS-associated ALS granules