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Inhibition of phospholipase D1 induces immunogenic cell death and potentiates cancer immunotherapy in colorectal cancer

Won Chan Hwang
Doona Song
Do Sik Min
ResearchOpen Access21 Sept 2022
Experimental & Molecular Medicine

Volume: 54, P: 1563-1576
Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model

Yongseok Choi
Song-Kyu Park
Gyoonhee Han
ResearchOpen Access31 Oct 2008
Experimental & Molecular Medicine

Volume: 40, P: 574-581
Chemical inhibition of prometastatic lysyl-tRNA synthetase–laminin receptor interaction

Beyond its canonical role in translation, lysyl-tRNA synthetase (KRS) stabilizes the prometastatic 67-kDa laminin receptor (67LR) in the plasma membrane. A small-molecule inhibitor of the KRS-67LR interaction modulates the KRS-promoted metastatic potential of 67LR without disrupting the normal function of each protein.

Dae Gyu Kim
Jin Young Lee
Sunghoon Kim
Research10 Nov 2013
Nature Chemical Biology

Volume: 10, P: 29-34
Small-molecule binding of the axin RGS ___domain promotes β-catenin and Ras degradation

A small-molecule compound binds to the RGS ___domain of axin, promotes the degradation of β-catenin and Ras through the GSK3β-mediated destruction complex, and reduces the growth of KRAS and APC mutant colorectal cancer cell lines.

Pu-Hyeon Cha
Yong-Hee Cho
Kang-Yell Choi
Research13 Jun 2016
Nature Chemical Biology

Volume: 12, P: 593-600
Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction

Leucyl-tRNA synthetase (LRS) is a leucine sensor of the mTORC1 pathway. Here, the authors identify inhibitors of the GTPase activating function of LRS, not affecting its catalytic activity, and demonstrate that the leucine sensor function of LRS can be a new target for mTORC1 inhibition.

Jong Hyun Kim
Chulho Lee
Sunghoon Kim
ResearchOpen Access29 Sept 2017
Nature Communications

Volume: 8, P: 1-15
Euodia sutchuenensis Dode extract stimulates osteoblast differentiation via Wnt/β-catenin pathway activation

Jeong-Ha Hwang
Pu-Hyeon Cha
Kang-Yell Choi
ResearchOpen Access20 Mar 2015
Experimental & Molecular Medicine

Volume: 47, P: e152
A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer

Jieun Park
Yong-Hee Cho
Kang-Yell Choi
ResearchOpen Access24 Jan 2019
Scientific Reports

Volume: 9, P: 1-11
PRMT5 promotes DNA repair through methylation of 53BP1 and is regulated by Src-mediated phosphorylation

Hwang et al. show that the activity of PRMT5 methyltransferase is regulated by Src kinase-mediated phosphorylation at Y324 in response to DNA damage. They also show that PRMT5 participates in NHEJ repair by regulating 53BP1 protein levels and is critical for cellular survival after DNA damage.

Jee Won Hwang
Su-Nam Kim
Yong Kee Kim
ResearchOpen Access05 Aug 2020
Communications Biology

Volume: 3, P: 1-13
A small molecule approach to degrade RAS with EGFR repression is a potential therapy for KRAS mutation-driven colorectal cancer resistance to cetuximab

Sang-Kyu Lee
Yong-Hee Cho
Kang-Yell Choi
ResearchOpen Access20 Nov 2018
Experimental & Molecular Medicine

Volume: 50, P: 1-12

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Inhibition of phospholipase D1 induces immunogenic cell death and potentiates cancer immunotherapy in colorectal cancer

Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model

Chemical inhibition of prometastatic lysyl-tRNA synthetase–laminin receptor interaction

Small-molecule binding of the axin RGS ___domain promotes β-catenin and Ras degradation

Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction

Euodia sutchuenensis Dode extract stimulates osteoblast differentiation via Wnt/β-catenin pathway activation

A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer

PRMT5 promotes DNA repair through methylation of 53BP1 and is regulated by Src-mediated phosphorylation

A small molecule approach to degrade RAS with EGFR repression is a potential therapy for KRAS mutation-driven colorectal cancer resistance to cetuximab

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