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Showing 1–5 of 5 results

Advanced filters: Author: Isabelle Eberl Clear advanced filters

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

Both environmental factors and genetic factors influence human immunity. Albert and colleagues leverage data from the Milieu Intérieur Consortium to comprehensively describe the effects of lifestyle, environment and genetics on human innate and adaptive immunity.

Etienne Patin
Milena Hasan
Matthew L. Albert
Research23 Feb 2018
Nature Immunology

Volume: 19, P: 302-314
Cell surface thermal proteome profiling tracks perturbations and drug targets on the plasma membrane

Cell surface thermal proteome profiling allows characterization of ligand-induced changes in protein abundances and thermal stabilities at the plasma membrane.

Mathias Kalxdorf
Ina Günthner
Marcus Bantscheff
Research04 Jan 2021
Nature Methods

Volume: 18, P: 84-91
Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes

Type 1 diabetes has a multifactorial etiology. Lehuen and colleagues demonstrate that MAIT cells serve both positive roles and negative roles in type 1 diabetes by maintaining gut integrity and limiting pancreatic inflammation but also directly destroying β-cells.

Ophélie Rouxel
Jennifer Da silva
Agnès Lehuen
Research09 Oct 2017
Nature Immunology

Volume: 18, P: 1321-1331
Identifying drug targets in tissues and whole blood with thermal-shift profiling

The targets of small-molecule drugs are detected in tissue and blood using thermal proteome assays.

Jessica Perrin
Thilo Werner
Giovanna Bergamini
Research20 Jan 2020
Nature Biotechnology

Volume: 38, P: 303-308
Endotracheal tube biofilm in critically ill patients during the COVID-19 pandemic : description of an underestimated microbiological compartment

Thomas Maldiney
Valentin Pineau
Jean-Pierre Quenot
ResearchOpen Access27 Dec 2022
Scientific Reports

Volume: 12, P: 1-13