Nature Search

Concordant methylation of the ER and N33 genes in glioblastoma multiforme

Qing Li
Ann Jedlicka
Jean-Pierre J Issa
Research17 Jun 1998
Oncogene

Volume: 16, P: 3197-3202
Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

Jean-Pierre J. Issa
Yvonne L. Ottaviano
Stephen B. Baylin
Research01 Aug 1994
Nature Genetics

Volume: 7, P: 536-540
Azacitidine

Jean-Pierre J. Issa
Hagop M. Kantarjian
Peter Kirkpatrick
Comments & Opinion01 Apr 2005
Nature Reviews Drug Discovery

Volume: 4, P: 275-276
Optimizing therapy with methylation inhibitors in myelodysplastic syndromes: dose, duration, and patient selection

Jean-Pierre Issa
Reviews01 Dec 2005
Nature Clinical Practice Oncology

Volume: 2, P: S24-S29
Epigenetics and human disease

Altered IGF2 imprinting in somatic overgrowth provides further evidence for the involvement of epigenetics in human disease (pages 311–316).

Jean-Pierre J. Issa
Stephen B. Baylin
News & Views01 Mar 1996
Nature Medicine

Volume: 2, P: 281-282
p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3

Michele Makos Wales
Margaret A. Biel
Stephen B. Baylin
Research01 Jun 1995
Nature Medicine

Volume: 1, P: 570-577
Effect of 677 C to T mutations in the methylenetetrahydrofolate reductase gene, folate intake and plasma homocysteine on adenoma recurrence

Maria Elena Martinez
Janine Einspahr
David S. Alberts
Research Highlights01 Apr 2001
Nature Genetics

Volume: 27, P: 72
Epigenetic variation and cellular Darwinism

The human genome contains large areas with hypervariable DNA methylation that are associated with deregulation of gene expression. This epigenetic variation may be necessary for differentiation, but it also provides a mechanism for Darwinian evolution at the cellular level that may underlie age-related diseases such as cancer.

Jean-Pierre Issa
News & Views27 Jul 2011
Nature Genetics

Volume: 43, P: 724-726
Chromosome 5q deletion and epigenetic suppression of the gene encoding α-catenin (CTNNA1) in myeloid cell transformation

Ting Xi Liu
Michael W Becker
A Thomas Look
Research10 Dec 2006
Nature Medicine

Volume: 13, P: 78-83
Cellular Heterogeneity–Adjusted cLonal Methylation (CHALM) improves prediction of gene expression

Here, the authors introduce Cell Heterogeneity–Adjusted cLonal Methylation (CHALM) as a methylation quantification method that considers the heterogeneity of sequenced bulk cells. They apply CHALM to methylation datasets to detect differentially methylated genes that exhibit distinct biological functions supporting underlying mechanisms.

Jianfeng Xu
Jiejun Shi
Wei Li
ResearchOpen Access15 Jan 2021
Nature Communications

Volume: 12, P: 1-9
Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas

It is known that invasive lung adenocarcinomas evolve from pre-cancerous dysplastic lesions. In this study, the authors show that evolution of pre-cancerous lesions is accompanied by DNA methylation alterations, and that global hypomethylation correlates with immune infiltration, mutational burden and copy number alterations.

Xin Hu
Marcos R. Estecio
Jianjun Zhang
ResearchOpen Access29 Jan 2021
Nature Communications

Volume: 12, P: 1-13
Methylation and silencing of the Thrombospondin-1 promoter in human cancer

Qing Li
Nita Ahuja
Jean-Pierre J Issa
Research25 May 1999
Oncogene

Volume: 18, P: 3284-3289
Ezh2 phosphorylation state determines its capacity to maintain CD8⁺ T memory precursors for antitumor immunity

During an immune response naive CD8⁺ T cells can differentiate into either effector or memory T cells. Here the authors show that Akt-mediated phosphorylation of the epigenetic regulator Ezh2 is critical for the generation of an anti-tumor CD8 T cell response and promotes the expansion of memory-precursors.

Shan He
Yongnian Liu
Yi Zhang
ResearchOpen Access14 Dec 2017
Nature Communications

Volume: 8, P: 1-14
CpG island methylator phenotype in cancer

Jean-Pierre Issa
Reviews01 Dec 2004
Nature Reviews Cancer

Volume: 4, P: 988-993
Caloric restriction delays age-related methylation drift

Caloric restriction has been shown to increase lifespan in mammals. Here, the authors provide evidence that age-related methylation drift correlates with lifespan and that caloric restriction in mice and rhesus monkeys results in attenuation of age-related methylation drift.

Shinji Maegawa
Yue Lu
Jean-Pierre J. Issa
ResearchOpen Access14 Sept 2017
Nature Communications

Volume: 8, P: 1-11
G9a is essential for epigenetic silencing of K⁺ channel genes in acute-to-chronic pain transition

Chronic neuropathic pain is associated with K⁺ channel downregulation in primary sensory neurons. The authors show that G9a, a histone-modifying enzyme, is required for transcriptional repression of K⁺ channel–associated gene families caused by nerve injury. G9a in primary sensory neurons is a key epigenetic regulator involved in acute-to-chronic pain transition.

Geoffroy Laumet
Judit Garriga
Hui-Lin Pan
Research09 Nov 2015
Nature Neuroscience

Volume: 18, P: 1746-1755
Dnmt3a is essential for hematopoietic stem cell differentiation

Margaret Goodell, Wei Li and colleagues report conditional ablation of the Dnmt3a DNA methyltransferase in hematopoietic stem cells (HSCs) in mice. They show that Dnmt3a is critical for epigenetic silencing of HSC regulatory genes and for HSC differentiation.

Grant A Challen
Deqiang Sun
Margaret A Goodell
Research04 Dec 2011
Nature Genetics

Volume: 44, P: 23-31
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation

Yutaka Kondo
Lanlan Shen
Jean-Pierre J Issa
Research18 May 2008
Nature Genetics

Volume: 40, P: 741-750
Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors

Takefumi Kikuchi
Minoru Toyota
Kohzoh Imai
Research24 Apr 2002
Oncogene

Volume: 21, P: 2741-2749
Targeting the cancer epigenome for therapy

Recent drug discovery efforts in cancer have focused on epigenetic marks, such as DNA methylation and histone modifications. The authors discuss existing therapeutics that target the cancer epigenome, the role of epigenetic marks as biomarkers of drug response and emerging strategies that combine epigenetic drugs with other cancer therapies.

Peter A. Jones
Jean-Pierre J. Issa
Stephen Baylin
Reviews15 Sept 2016
Nature Reviews Genetics

Volume: 17, P: 630-641
Hypomethylation of LINE-1 and Alu in well-differentiated neuroendocrine tumors (pancreatic endocrine tumors and carcinoid tumors)

In-Seon Choi
Marcos R H Estecio
Asif Rashid
Research04 May 2007
Modern Pathology

Volume: 20, P: 802-810
Hypomethylation of long interspersed nuclear element-1 in hepatocellular carcinomas

Mi-Jung Kim
Jill A White-Cross
Asif Rashid
Research09 Jan 2009
Modern Pathology

Volume: 22, P: 442-449
Comparison of Epigenetic and Genetic Alterations in Mucinous Cystic Neoplasm and Serous Microcystic Adenoma of Pancreas

Sang Geol Kim
Tsung-Teh Wu
Asif Rashid
Research01 Nov 2003
Modern Pathology

Volume: 16, P: 1086-1094
Demethylator phenotypes in acute myeloid leukemia

Andrew D. Kelly
Jozef Madzo
Jean-Pierre J. Issa
Research07 Mar 2018
Leukemia

Volume: 32, P: 2178-2188
Gestational high fat diet protects 3xTg offspring from memory impairments, synaptic dysfunction, and brain pathology

Antonio Di Meco
Jaroslav Jelinek
Domenico Praticò
Research27 Aug 2019
Molecular Psychiatry

Volume: 26, P: 7006-7019
Microbial Colonization Coordinates the Pathogenesis of a Klebsiella pneumoniae Infant Isolate

Jillian L. Pope
Ye Yang
Christian Jobin
ResearchOpen Access04 Mar 2019
Scientific Reports

Volume: 9, P: 1-13
Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties

Joseph H. Taube
Gabriel G. Malouf
Sendurai A. Mani
ResearchOpen Access18 Sept 2013
Scientific Reports

Volume: 3, P: 1-10
CpG island methylation in carcinoid and pancreatic endocrine tumors

Annie On-On Chan
Sang Geol Kim
Asif Rashid
Research13 Feb 2003
Oncogene

Volume: 22, P: 924-934
Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy

Tadeusz Majewski
Sangkyou Lee
Bogdan Czerniak
Research05 May 2008
Laboratory Investigation

Volume: 88, P: 694-721

Search

Concordant methylation of the ER and N33 genes in glioblastoma multiforme

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

Azacitidine

Optimizing therapy with methylation inhibitors in myelodysplastic syndromes: dose, duration, and patient selection

Epigenetics and human disease

p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3

Effect of 677 C to T mutations in the methylenetetrahydrofolate reductase gene, folate intake and plasma homocysteine on adenoma recurrence

Epigenetic variation and cellular Darwinism

Chromosome 5q deletion and epigenetic suppression of the gene encoding α-catenin (CTNNA1) in myeloid cell transformation

Cellular Heterogeneity–Adjusted cLonal Methylation (CHALM) improves prediction of gene expression

Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas

Methylation and silencing of the Thrombospondin-1 promoter in human cancer

Ezh2 phosphorylation state determines its capacity to maintain CD8⁺ T memory precursors for antitumor immunity

CpG island methylator phenotype in cancer

Caloric restriction delays age-related methylation drift

G9a is essential for epigenetic silencing of K⁺ channel genes in acute-to-chronic pain transition

Dnmt3a is essential for hematopoietic stem cell differentiation

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation

Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors

Targeting the cancer epigenome for therapy

Hypomethylation of LINE-1 and Alu in well-differentiated neuroendocrine tumors (pancreatic endocrine tumors and carcinoid tumors)

Hypomethylation of long interspersed nuclear element-1 in hepatocellular carcinomas

Comparison of Epigenetic and Genetic Alterations in Mucinous Cystic Neoplasm and Serous Microcystic Adenoma of Pancreas

Demethylator phenotypes in acute myeloid leukemia

Gestational high fat diet protects 3xTg offspring from memory impairments, synaptic dysfunction, and brain pathology

Microbial Colonization Coordinates the Pathogenesis of a Klebsiella pneumoniae Infant Isolate

Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties

CpG island methylation in carcinoid and pancreatic endocrine tumors

Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy

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