Search

Substituted 1,3,4-thiadiazoles find extensive use in pharmaceutical, agricultural, and materials chemistry. Herein, the authors report the synthesis of multi-functionalized 1,3,4- thiadiazoles via sulfur-mediated direct coupling between primary nitroalkanes and acyl hydrazines.

Here, the authors develop an antiferromagnet/topological insulator heterostructure, MnSe/(Bi,Sb)₂Te₃, to obtain laser-induced transient magnetic moment and optically controllable circularly polarized ultrafast terahertz pulse generation, under zero external magnetic field.

High-energy aqueous metal batteries are promising candidates for the next-generation energy storage systems yet face detrimental parasitic reactions. Here, authors develop a durable cadmium-metal battery employing a fast-kinetics dual-structure-breaking electrolyte.

Addressing the stability challenges from metal electrodes/perovskite components chemical interactions is essential for high-performance perovskite solar cells. Here, authors design a bilayer polymer buffer to mitigate metal/ion interdiffusion, realizing a certified efficiency of 26.46%.

The utilization of Mg₃(Sb,Bi)₂ in thermoelectric devices is hindered by its low performance near room temperature. Here, authors report thermoelectric performance enhancement of Mg₃(Sb,Bi)₂ within a wide temperature range by incorporating metallic inclusions at grain boundaries. (279 in total)

MorphLink is a computational framework that links tissue morphology changes to molecular alterations using spatial omics data, providing intuitive visualisations of cellular behaviours from both structural and molecular perspectives.

A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

Lactobacillus-based probiotics have been reported to be beneficial for colitis through incompletely understood mechanisms. Here the authors identify an uncharacterized secreted enzyme named LPH from multiple probiotic Lactobacillus strains, which protects female mice from chemically induced colitis and colorectal cancer via NOD2 signalling.

The direct electro-reduction of diluted CO₂ in acidic media can circumvent CO₂ purification and reduce carbon loss. Here, the authors use an ionomer coating layer to enrich the diluted CO₂ and block proton transport, thereby achieving high carbon utilization in diluted CO₂ in an acidic electrolyte.

The new kagome metals can exhibit unconventional electron correlated states beyond recently discovered kagome superconductors AV₃Sb₅. Here, the authors report discovery of superconductivity and intrinsic nematic order in a new titanium-based kagome metal CsTi₃Bi₅ without charge density wave order.

Liu et al. developed a framework called ARNLE to explore host tropism of SARS-CoV-2 and found a shift from weak to strong primate tropism. Key mutations involved in this shift can be analysed to advance research on emerging viruses.

Doping approach is a conventional method to increase ZT values of thermoelectric materials. Here, authors propose a facile strategy to enhance thermoelectric performance by mixing boron particles into GeTe-based thermoelectric materials, leading to a ZT value of 2.45 at 613 K.

The authors achieve piezoelectric coefficient d₃₃ ∼ 807 pC·N⁻¹, along with high k₃₃ ∼ 88 % and T_c ∼ 245 °C in (K,Na)(Nb_1-xSb_x)O₃-Bi_0.5Na_0.5ZrO₃-BiFeO₃ system through structural flexibility and grain orientation strategies.

The unique band structure of topological insulators gives rise to insulating bulk and unusual metallic surface properties. By tuning the content of Sb in the ternary compound (Bi_1–xSb_x)₂Te₃, Wang and collaborators show it is possible to control the precise features of the band structure in a continuous fashion.

The long-term stability of perovskite solar cells remains a critical challenge for the commercialization of the technology. Here, the authors adopt a non-noble metal/metal oxide/polymer multiple-barrier to suppress device degradation, achieving long-term stability in encapsulated p-i-n devices.

A multimodal model for the stratification of breast cancer risk based on clinical metadata, mammography and trimodal ultrasound images performed as well as or better than radiologists at tumour classification and at differential diagnosis.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

In Bi₂O₂Se thin films, the local inversion-symmetry breaking in two sectors of the [Bi₂O₂]²⁺ layer yields opposite Rashba spin polarizations, which compensate each other and give rise to the hidden Rashba effect. Hence, the films exhibit only even-integer quantum Hall states, but there is no sign of odd-integer states.

Future spintronic devices may exploit topological insulators, bulk insulators with unique spin-momentum locked conductive surface states. Here, the authors demonstrate the detection of thermally-generated spin currents in a ferromagnetic-insulator/topological-insulator heterostructure.

The intrinsic high-concentration Ge vacancies in GeTe-based thermoelectric materials hinder their performance maximization. Here, the authors find that defect structure engineering strategy is effective for performance enhancement.

Cross-ancestry and sex-stratified genome-wide association analyses for 21 amygdala volumetric traits in East Asian and European individuals provide insight into the genetic architectures of amygdala and subnucleus volumes.

The H9N2 avian influenza viruses (AIVs) remain dominant in live poultry markets in China, and H9N2 AIVs with HA-Q226L, PB2-V/K627 and NP-N52 mutations can be transmitted between guinea pigs and between ferrets via direct contact and respiratory droplet.

Electric contacts of semimetallic bismuth on monolayer semiconductors are shown to suppress metal-induced gap states and thus have very low contact resistance and a zero Schottky barrier height.

An explainable deep-learning system prospectively predicts clinical scores for breast cancer risk from multimodal breast-ultrasound images as accurately as experienced radiologists.

Human NPCs show promise for stroke treatment, but challenges remain in neuron diversity and maturation time. Here, the authors describe the generation of FOXG1 progenitors from iPSCs that quickly mature into functional cortical neurons, enhancing stroke recovery in rats.

Kagome superconductors are a platform for intertwined condensed matter phenomena that may be mediated by band topology. Here, authors use ARPES and DFT to identify type-II Dirac nodal lines, flat bands, topologically non-trivial surface states and signatures of nematicity in the kagome compound RbTi₃Bi₅.

A novel covalent inhibitor, ISM3312, targets the main protease of multiple human coronaviruses, including drug-resistant strains, and shows broad antiviral activity. It offers a promising therapeutic strategy against current and future coronavirus threats.

A nonstoichiometric CaGa_xO₄:Bi (x < 2) design introduces compositional defects that generate various traps near Bi ions, enabling excitation-wavelength-dependent persistent luminescence (PersL) and holding promise for advanced anti-counterfeiting applications.

The technological development requires the future advanced combustion engines be designed to operate at low temperature. Here, the authors show that partially oxide Pt-[O]_x-Bi interface catalyzes CO oxidation at ~ 50 °C via providing moderate CO adsorption and activating CO molecules with electron transformation.

Here, the authors demonstrate how targeted memory reactivation during NREM sleep enhances memory consolidation through repeated reactivations, characterized by increased hippocampal ripples, cortical spindles, and dynamic hippocampal-cortical interactions.

Axions are hypothetical particles that might play an important part in particle physics, astrophysics and cosmology. So far they have eluded observation, but theoretical work now predicts that axion physics might be explored in condensed-matter systems known as topological insulators.

The mantle has contributed more largely to tungsten mineralization processes and tungsten pre-enrichment in the crust than previously thought, based on multi-isotope data analysis of major tungsten provinces worldwide coupled with machine learning.

Radiation-hardened electrostatic dielectric capacitors are critical components in advanced electronic and electrical systems. Here, the authors demonstrate a high-energy-density and radiation-tolerant capacitor by constructing a dendritic-like structured ferroelectric embedded in an insulator.

Kagome superconductors host a panoply of condensed matter phenomena, some of which are mediated by band topology. Here, authors use ARPES and DFT to identify type-II and type-III Dirac nodal lines, flat bands and topological surface states in the kagome metal CsTi₃Bi₅.

The authors investigate junctions made of two flakes of the cuprate superconductor Bi₂Sr_2-xLa_xCuO_6+y (Bi2201) twisted by 45 degrees. They find evidence for an isotropic pairing component, and call into question theoretical predictions of d+id superconductivity in this system.

Succinylation of PD-L1 by carnitine palmitoyltransferase 1A (CPT1A) in melanoma leads to its degradation and enhanced T cell-dependent killing in vitro. Increasing CPT1A levels synergizes with anti-CTLA-4 treatment to suppress tumor growth in a mouse melanoma model.

Aumolertinib is a third generation EGFR tyrosine kinase inhibitors, approved for use in patients with advanced EGFR-mutant non-small cell lung cancer (NSCLC). Here, the authors report a phase 2 clinical trial investigating neoadjuvant aumolertinib in patients with unresectable stage III EGFR-mutant NSCLC.

Aromatic Cr₅ planes, capped by Sn atoms and enclosed within a large binary main-group molecular cage, are reported. This stabilizing framework facilitates the capture of metastable Cr clusters, providing insights into Cr–Cr bonding.

We investigated the origins of charge density wave (CDW) mechanisms in the bi-layered kagome metal ScV₆Sn₆ by comparing its electronic structure with that of its isostructural counterpart YV₆Sn₆, which does not exhibit a CDW state. Our ARPES measurements reveal that the Van Hove singularity (VHS) nesting mechanism may not be valid in the CDW state. In ScV₆Sn₆, the electronic structure shows a CDW-induced band gap accompanied by anomalous band dispersion near the M point of the Brillouin zone. These findings provide experimental evidence for the origin of CDW in vanadium-based kagome metals.

The anomalous Hall (AH) effect in magnetically doped topological insulator has been elusive. Here, Liu et al. observe that the AH resistance changes sign in the Mn doped Bi₂Se₃ thin films, where bulk (surface) states contribute to positive (negative) AH components dominantly.

Two-dimensional chalcogenides offer great potential in electronics, but accurate control of their growth is difficult. Here, the authors combine microintaglio printing and van der Waals epitaxy to pattern various large-area arrays of single-crystal chalcogenides with remarkable properties.

The authors report the large low-field-driven electrocaloric effect in the novel organic-inorganic hybrid TMCM-CdCl₃, underlyingly from the disordering of organic cations and the low-symmetry interaction induced two-step meta-electric transition.

KRas is frequently mutated in multiple cancer types; identifying drugs to treat such cancers is a good therapeutic strategy. Here, the authors perform a synthetic lethal screen in mice and show that inhibiting Plk1 and ROCK results in the inhibition of tumour growth by increasing expression of the tumour suppressor p21.

Exploring the helicity-orbital coupling induced skyrmion properties is essential for the spintronic applications. Here the authors report the current controlled skyrmions and antiskyrmions dynamics with locking-unlocking helicity in frustrated magnets by including the dipole-dipole interaction in their model.

The electrical resistivity of Fermi liquids usually shows square power law with respect to temperature (T²) due to either inter-bandscattering or Umklapp process. Here, authors report T² resitivity below a temperature where neither Umkapp nor interband scattering is responsible in a dilute metal Bi₂O₂Se.