Nature Search

Federated learning enables big data for rare cancer boundary detection

Federated ML (FL) provides an alternative to train accurate and generalizable ML models, by only sharing numerical model updates. Here, the authors present the largest FL study to-date to generate an automatic tumor boundary detector for glioblastoma.

Sarthak Pati
Ujjwal Baid
Spyridon Bakas
ResearchOpen Access05 Dec 2022
Nature Communications

Volume: 13, P: 1-17
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

Joanna Howson and colleagues perform a genome-wide association study and meta-analysis for coronary artery disease in large, trans-ancestry cohorts. They identify 15 new loci and correlate these regions with cell-type-specific gene expression and plasma protein levels to find novel pathways and potential mechanisms of disease.

Joanna M M Howson
Wei Zhao
Danish Saleheen
Research22 May 2017
Nature Genetics

Volume: 49, P: 1113-1119
From developmental disorder to heritable cancer: it's all in the BMP/TGF-β family

Kristin A. Waite
Charis Eng
Reviews01 Oct 2003
Nature Reviews Genetics

Volume: 4, P: 763-773
Discovery and refinement of loci associated with lipid levels

Cristen Willer and colleagues report genome-wide association analyses for blood lipid levels in 188,578 individuals. They identify 62 loci newly associated with blood lipid levels, refine the association signals at 12 loci and examine associations with cardiovascular and metabolic traits.

Cristen J Willer
Ellen M Schmidt
Gonçalo R Abecasis
Research06 Oct 2013
Nature Genetics

Volume: 45, P: 1274-1283
Common variants associated with plasma triglycerides and risk for coronary artery disease

Sekar Kathiresan and colleagues examine 185 common variants using a modified mendelian randomization approach and provide evidence supporting a causal role of triglyceride-rich lipoproteins in the development of coronary artery disease.

Ron Do
Cristen J Willer
Sekar Kathiresan
Research06 Oct 2013
Nature Genetics

Volume: 45, P: 1345-1352
Author Correction: Federated learning enables big data for rare cancer boundary detection

Sarthak Pati
Ujjwal Baid
Spyridon Bakas
Amendments and CorrectionsOpen Access26 Jan 2023
Nature Communications

Volume: 14, P: 1-2
Racial disparities in breast cancer treatment patterns and treatment related adverse events

Nickolas Stabellini
Jennifer Cullen
Alberto J. Montero
ResearchOpen Access22 Jan 2023
Scientific Reports

Volume: 13, P: 1-10
Sex differences in esophageal cancer overall and by histological subtype

Nickolas Stabellini
Apoorva Krishna Chandar
Jill S. Barnholtz-Sloan
ResearchOpen Access28 Mar 2022
Scientific Reports

Volume: 12, P: 1-13

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