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Showing 1–3 of 3 results

Advanced filters: Author: Liu-zheng Wu Clear advanced filters

Full-length GSDME mediates pyroptosis independent from cleavage

Zhou, Jiang, Dai et al report that upon ultraviolet-C radiation, full-length GSDME can induce pyroptosis without cleavage, likely due to conformational change and oxidative oligomerization after increased PARylation and mitochondrial lipid ROS levels.

Bo Zhou
Zhi-hong Jiang
Qiao Wu
Research12 Jul 2024
Nature Cell Biology

Volume: 26, P: 1545-1557
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma

Hexokinase 1 is found to be secreted from hepatic stellate cells in large extracellular vesicles in response to TGF-β, and is subsequently taken up by hepatocellular carcinoma cells, where it promotes tumor progression and metastasis.

Qi-tao Chen
Zhi-yuan Zhang
Qiao Wu
ResearchOpen Access03 Oct 2022
Nature Metabolism

Volume: 4, P: 1306-1321
Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P

Yuan-li Ai
Wei-jia Wang
Qiao Wu
ResearchOpen Access17 Jul 2023
Cell Research

Volume: 33, P: 904-922