The levels of m6A and WTAP are elevated in the CD4+ T cells of tolerant kidney transplant recipients. In naïve CD4+ T cells from kidney transplant recipients with immune rejection, WTAP is highly expressed and facilitates Foxo1 transcription by enhancing m6A modification of Foxo1 mRNA in the CDS region, which enhances Foxo1-mediated Foxp3 transcription and subsequent Treg cell differentiation and function.
- Zhigang Wang
- Yuanbo Qi
- Wenjun Shang
