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Cardiac and liver impairment on multiorgan MRI and risk of major adverse cardiovascular and liver events

In 28,841 individuals who underwent cardiac and liver MRI before being followed for a median of 4.3 years, detection of both liver and cardiac impairment by MRI was associated with cardiovascular- and liver-related hospitalization.

Edward Jackson
Andrea Dennis
Amitava Banerjee
ResearchOpen Access07 May 2025
Nature Medicine

P: 1-8
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

Lipophilic siRNA conjugates exert therapeutic activity in the mouse CNS.

Kirk M. Brown
Jayaprakash K. Nair
Vasant Jadhav
Research02 Jun 2022
Nature Biotechnology

Volume: 40, P: 1500-1508
Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity

A subset of chemically-modified siRNAs conjugated to trivalent GalNAc may fail during nonclinical development due to rat hepatotoxicity. Here, the authors show that hepatotoxicity may be accounted for by microRNA-like off-target effects of siRNA and can be mitigated by a thermally destabilizing modification in the siRNA seed region.

Maja M. Janas
Mark K. Schlegel
Vasant Jadhav
ResearchOpen Access19 Feb 2018
Nature Communications

Volume: 9, P: 1-10
Reversal of siRNA-mediated gene silencing in vivo

Gene silencing by siRNAs in vivo is reversed using sequence-specific high-affinity oligonucleotides.

Ivan Zlatev
Adam Castoreno
Vasant Jadhav
Research14 May 2018
Nature Biotechnology

Volume: 36, P: 509-511
Rational design of cationic lipids for siRNA delivery

Efficient siRNA delivery remains a key challenge to realizing the full potential of RNAi-based therapeutics. Semple et al. accomplish unprecedented potency for liposome-mediated siRNA delivery by applying rational design to refine an empirically identified cationic lipid widely regarded as the benchmark for use in lipid nanoparticles.

Sean C Semple
Akin Akinc
Michael J Hope
Research17 Jan 2010
Nature Biotechnology

Volume: 28, P: 172-176
A murine model demonstrating reversal of structural and functional correlates of cirrhosis with progenitor cell transplantation

Mark D. Muthiah
Daniel Q. Huang
Yock-Young Dan
ResearchOpen Access28 Oct 2019
Scientific Reports

Volume: 9, P: 1-12
Platform for the interdisciplinary study of cardiovascular, metabolic and neurovascular diseases (PICMAN) protocol

Mayank Dalakoti
Melvin Khee Shing Leow
Roger Foo
ResearchOpen Access22 Nov 2023
Scientific Reports

Volume: 13, P: 1-10
Efficacy and safety of tirzepatide for treatment of overweight or obesity. A systematic review and meta-analysis

Bryan Tan
Xin-Hui Pan
Yip Han Chin
Reviews31 May 2023
International Journal of Obesity

Volume: 47, P: 677-685

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Cardiac and liver impairment on multiorgan MRI and risk of major adverse cardiovascular and liver events

Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity

Reversal of siRNA-mediated gene silencing in vivo

Rational design of cationic lipids for siRNA delivery

A murine model demonstrating reversal of structural and functional correlates of cirrhosis with progenitor cell transplantation

Platform for the interdisciplinary study of cardiovascular, metabolic and neurovascular diseases (PICMAN) protocol

Efficacy and safety of tirzepatide for treatment of overweight or obesity. A systematic review and meta-analysis

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