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Imbalanced TGFβ signalling and autophagy drive erythroid priming of hematopoietic stem cells in β-thalassemia

Here, the authors show how in β-thalassemia, a perturbed bone marrow microenvironment leads to altered hematopoiesis. Reduced TGFβ reduces autophagy levels, in turn reducing dormancy and priming of haematopoietic stem cells and multipotent progenitors towards erythroid lineage.

Maria Rosa Lidonnici
Giulia Chianella
Giuliana Ferrari
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-19
Author Correction: Genotoxic effects of base and prime editing in human hematopoietic stem cells

Martina Fiumara
Samuele Ferrari
Luigi Naldini
Amendments and CorrectionsOpen Access25 Jan 2024
Nature Biotechnology

Volume: 42, P: 986
Longitudinal single-cell profiling of chemotherapy response in acute myeloid leukemia

Relapse within acute myeloid leukaemia may be driven by the presence of leukaemia stem cells. Here, the authors use single cell RNA-seq seq to characterise leukemia stem cells, and show miR-126 as a potential marker of resistance.

Matteo Maria Naldini
Gabriele Casirati
Bernhard Gentner
ResearchOpen Access08 Mar 2023
Nature Communications

Volume: 14, P: 1-20
Genotoxic effects of base and prime editing in human hematopoietic stem cells

Base and prime editors induce double-strand breaks, deletions and translocations in hematopoietic cells.

Martina Fiumara
Samuele Ferrari
Luigi Naldini
ResearchOpen Access07 Sept 2023
Nature Biotechnology

Volume: 42, P: 877-891
Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation

Post-transplantation relapse in acute myeloid leukemia patients without genomic loss of HLA is driven by transcriptional alterations in antigen presentation and T cell costimulation genes.

Cristina Toffalori
Laura Zito
Luca Vago
Research25 Mar 2019
Nature Medicine

Volume: 25, P: 603-611
A case of T-cell acute lymphoblastic leukemia in retroviral gene therapy for ADA-SCID

Leukaemia development has been reported as an associated risk of haematopoietic stem cell gene therapy (HSPC-GT) using retroviral vectors in different diseases. Here, the authors show a case of T-cell acute lymphoid leukaemia in a patient with Adenosine Deaminase-deficient Severe Combined Immunodeficiency (ADA-SCID) treated with retroviral gene therapy.

Daniela Cesana
Maria Pia Cicalese
Alessandro Aiuti
ResearchOpen Access30 Apr 2024
Nature Communications

Volume: 15, P: 1-18
gDNA qPCR is statistically more reliable than mRNA analysis in detecting leukemic cells to monitor CML

Alessia Rainero
Fabrizio Angaroni
Giovanni Porta
ResearchOpen Access02 Mar 2018
Cell Death & Disease

Volume: 9, P: 1-8
Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Ilja M. Nolte
M. Loretto Munoz
Eco J. C. de Geus
Amendments and CorrectionsOpen Access02 Aug 2017
Nature Communications

Volume: 8, P: 1-2
Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Heart rate variability (HRV) describes the individual variation in cardiac cycle duration and is a measure of vagal control of heart rate. Here, the authors identify seventeen single-nucleotide polymorphisms associated with HRV, lending new insight into the vagal regulation of heart rhythm.

Ilja M. Nolte
M. Loretto Munoz
Eco J. C. de Geus
ResearchOpen Access14 Jun 2017
Nature Communications

Volume: 8, P: 1-17
miR-126 identifies a quiescent and chemo-resistant human B-ALL cell subset that correlates with minimal residual disease

Carolina Caserta
Silvia Nucera
Bernhard Gentner
Research28 Aug 2023
Leukemia

Volume: 37, P: 1994-2005
Modelling the COVID-19 epidemic and implementation of population-wide interventions in Italy

A new epidemiological model, termed SIDARTHE, distinguishes between diagnosed and undiagnosed cases of SARS-CoV-2 infection, as well as modeling effects of social distancing and widespread testing, to predict possible outcomes of the COVID-19 epidemic in Italy.

Giulia Giordano
Franco Blanchini
Marta Colaneri
Research22 Apr 2020
Nature Medicine

Volume: 26, P: 855-860
Video clips for patient comprehension of atrial fibrillation and deep vein thrombosis in emergency care. A randomised clinical trial

Santi Di Pietro
Ilaria Ferrari
Ilaria Zunino
ResearchOpen Access30 Apr 2024
npj Digital Medicine

Volume: 7, P: 1-7

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