Controversy exists over the safety of testosterone replacement therapy (TRT) with regard to the initiation, promotion, aggressiveness, and progression of prostate cancer. In their Review, Goldenberg and colleagues argue the importance of classic early literature on the concept of a testosterone threshold level and the implications for use and safety of TRT, as well as describe the biological effects of TRT for testosterone deficiency.
- S. Larry Goldenberg
- Anthony Koupparis
- Michael E. Robinson
