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Transcriptional repression facilitates RNA:DNA hybrid accumulation at DNA double-strand breaks

Saur, Lesage et al. report that RNA:DNA hybrids arise at double-strand breaks in transcribed genes, independently of de novo recruitment of RNA polymerase II/III, as a result of DSB-induced transcriptional repression.

Florian Saur
Emma Lesage
Gaëlle Legube
ResearchOpen Access30 May 2025
Nature Cell Biology

Volume: 27, P: 992-1005
Author Correction: Chromatin compartmentalization regulates the response to DNA damage

Coline Arnould
Vincent Rocher
Gaëlle Legube
Amendments and CorrectionsOpen Access16 Nov 2023
Nature

Volume: 624, P: E1
A polymorphic stop codon in BRCA2

Sylvie Mazoyer
Alison M. Dunning
Gilbert M. Lenoir
Correspondence01 Nov 1996
Nature Genetics

Volume: 14, P: 253-254
Chromatin compartmentalization regulates the response to DNA damage

After the production of double-stranded breaks in mammalian cells, ATM drives the formation of the D compartment, which regulates DNA damage-responsive genes, through the clustering of damaged topologically associating domains, with a mechanism that is consistent with polymer–polymer phase separation.

Coline Arnould
Vincent Rocher
Gaëlle Legube
ResearchOpen Access18 Oct 2023
Nature

Volume: 623, P: 183-192
Endogenous factor VIII synthesis from the intron 22–inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A

Patients with hemophilia lacking functional coagulation factor VIII (FVIII) are treated with replacement FVIII proteins. The development of neutralizing antibodies to the replacement FVIII, a major clinical problem, depends on the nature of the mutation in the gene encoding FVIII. The authors find that a prevalent inversion allele can unexpectedly produce FVIII protein, explaining why individuals with this allele do not frequently develop neutralizing antibodies.

Gouri Shankar Pandey
Chen Yanover
Elaine Reed
Research15 Sept 2013
Nature Medicine

Volume: 19, P: 1318-1324
Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations

Recent studies suggest key roles of RNA in DNA double-strand breaks repair. Here the authors identify the helicase senataxin to be involved in DNA repair and resolve RNA:DNA hybrids forming at DNA double-strand breaks.

Sarah Cohen
Nadine Puget
Gaëlle Legube
ResearchOpen Access07 Feb 2018
Nature Communications

Volume: 9, P: 1-14
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

Gerard Schellenberg and colleagues report a genome-wide association study for progressive supranuclear palsy, a movement disorder with prominent tau neuropathology. They identified three new risk loci and confirmed the known risk locus at MAPT.

Günter U Höglinger
Nadine M Melhem
Gerard D Schellenberg
Research19 Jun 2011
Nature Genetics

Volume: 43, P: 699-705
DNA polymerase stalling, sister chromatid recombination and the BRCA genes

Ralph Scully
Nadine Puget
Katerina Vlasakova
Research11 Dec 2000
Oncogene

Volume: 19, P: 6176-6183
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

David Whitcomb, Bernie Devlin and colleagues report the results of a genome-wide association study of pancreatitis. They identify common variants at two loci associated with risk of this disease, including one on the X chromosome that shows strong evidence of interaction with alcohol consumption.

David C Whitcomb
Jessica LaRusch
Bernie Devlin
Research11 Nov 2012
Nature Genetics

Volume: 44, P: 1349-1354
Performance of the 12-item WHODAS 2.0 in prodromal Huntington disease

Ji-In Kim
Jeffrey D Long
Ryan Wyse
ResearchOpen Access04 Mar 2015
European Journal of Human Genetics

Volume: 23, P: 1584-1587

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Transcriptional repression facilitates RNA:DNA hybrid accumulation at DNA double-strand breaks

Author Correction: Chromatin compartmentalization regulates the response to DNA damage

A polymorphic stop codon in BRCA2

Chromatin compartmentalization regulates the response to DNA damage

Endogenous factor VIII synthesis from the intron 22–inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A

Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations

Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

DNA polymerase stalling, sister chromatid recombination and the BRCA genes

Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

Performance of the 12-item WHODAS 2.0 in prodromal Huntington disease

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