Nature Search

Local structural flexibility drives oligomorphism in computationally designed protein assemblies

This study reports unexpected structural diversity in computationally designed protein assemblies due to subunit flexibility. Fixing flexibility in one design restores the intended architecture, suggesting a strategy to design dynamic assemblies.

Alena Khmelinskaia
Neville P. Bethel
Neil P. King
ResearchOpen Access26 Feb 2025
Nature Structural & Molecular Biology

Volume: 32, P: 1050-1060
Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction

A national prospective study of patients requiring hospitalization for COVID-19 demonstrates global cognitive deficits at 1 year, associated with elevated brain injury markers and reduced gray matter volume.

Greta K. Wood
Brendan F. Sargent
E. Charles Leek
ResearchOpen Access23 Sept 2024
Nature Medicine

Volume: 31, P: 245-257
The quest for targetable pain mechanisms in 2024

Studies published in 2024 suggest that although the repurposing of established rheumatology drugs seems to deliver incremental benefits for pain management, greater benefits could be gained in the future by targeting newly discovered pain mechanisms.

Neil Basu
News & Views25 Nov 2024
Nature Reviews Rheumatology

Volume: 21, P: 69-70
¹⁸F-FDG-PET/MR imaging to monitor disease activity in large vessel vasculitis

Disease-monitoring in large vessel vasculitis is challenging, often leading to a mismatch between disease activity and treatment intensity. Here, the authors show that PET/MRI scanning can distinguish active from inactive large vessel vasculitis and track disease longitudinally, potentially allowing more stratified treatment for patients.

Dan Pugh
Dilip Patel
Neeraj Dhaun
ResearchOpen Access25 Aug 2024
Nature Communications

Volume: 15, P: 1-14
The characterization of Klebsiella pneumoniae associated with neonatal sepsis in low- and middle-income countries to inform vaccine design

A potential correlation between polysaccharide structural features and the ability of corresponding antibodies to bind and kill in vitro a large panel of Klebsiella pneumoniae clinical isolates, supporting the development of a multivalent vaccine.

Francesca Nonne
Mariagrazia Molfetta
Francesca Micoli
ResearchOpen Access09 Jun 2025
Communications Biology

Volume: 8, P: 1-12
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

COVID-19 can be associated with neurological complications. Here the authors show that markers of brain injury, but not immune markers, are elevated in the blood of patients with COVID-19 both early and months after SARS-CoV-2 infection, particularly in those with brain dysfunction or neurological diagnoses.

Benedict D. Michael
Cordelia Dunai
David K. Menon
ResearchOpen Access22 Dec 2023
Nature Communications

Volume: 14, P: 1-15
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Developmental Differences of Cystic Fibrosis Transmembrane Conductance Regulator Functional Expression in Isolated Rat Fetal Distal Airway Epithelial Cells

R John Macleod
J R Hamilton
Neil B Sweezey
Research01 Jan 1994
Pediatric Research

Volume: 35, P: 45-49
RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage

The BRCA1-PALB2-BRCA2-RAD51 (BRCA1-P) complex is well known to play a fundamental role in DNA repair, but how the complex recruitment is regulated is still a matter of interest. Here the authors reveal mechanistic insights into RNF168 activity being responsible for PALB2 recruitment, through BARD1-BRCA1 during homologous recombination repair.

John J. Krais
Yifan Wang
Neil Johnson
ResearchOpen Access18 Aug 2021
Nature Communications

Volume: 12, P: 1-12
SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease

Serological analysis and infection outcomes of participants in the multi-center, prospectively enrolled OCTAVE cohort, comprising 2,686 participants with immune-suppressive diseases who recieved two COVID-19 vaccines, reveals specific clinical phenotypes that might benefit from specific COVID-19 therapeutic strategies.

Eleanor Barnes
Carl S. Goodyear
Deborah Richardson
ResearchOpen Access06 Jul 2023
Nature Medicine

Volume: 29, P: 1760-1774
Fatty acid transport protein 2 reprograms neutrophils in cancer

The lipid transporter FATP2 reprograms neutrophils to polymorphonuclear myeloid-derived suppressor cells by mediating the uptake of arachidonic acid and promoting the synthesis of prostaglandin E₂.

Filippo Veglia
Vladimir A. Tyurin
Dmitry I. Gabrilovich
Research17 Apr 2019
Nature

Volume: 569, P: 73-78
Design of target specific peptide inhibitors using generative deep learning and molecular dynamics simulations

Here the authors report a computational approach which integrates deep learning and structural modelling to design target-specific peptides. They apply this to β-catenin and NF-κB essential modulator, resulting in improved binding, highlighting the efficacy of this strategy.

Sijie Chen
Tong Lin
Xiaolin Cheng
ResearchOpen Access21 Feb 2024
Nature Communications

Volume: 15, P: 1-20
Catalytic generation of N₂O₃ by the concerted nitrite reductase and anhydrase activity of hemoglobin

Swati Basu
Rozalina Grubina
Daniel B Kim-Shapiro
Research04 Nov 2007
Nature Chemical Biology

Volume: 3, P: 785-794
Hypothetical model ignores many important pathophysiologic mechanisms in fibromyalgia

Daniel J. Clauw
Ernest H. S. Choy
Gary J. Macfarlane
Correspondence24 Mar 2023
Nature Reviews Rheumatology

Volume: 19, P: 321
Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Benedict D. Michael
Cordelia Dunai
David K. Menon
Amendments and CorrectionsOpen Access04 Apr 2024
Nature Communications

Volume: 15, P: 1
Hospital contribution to variation in rates of vaginal birth after cesarean

Jourdan E. Triebwasser
Neil S. Kamdar
Daniel M. Morgan
Research05 Apr 2019
Journal of Perinatology

Volume: 39, P: 904-910
A multi-modal MRI study of the central response to inflammation in rheumatoid arthritis

Many diseases, such as rheumatoid arthritis, are characterized by a chronic inflammatory state, but it is not clear whether or how this affects the brain. Here, the authors show that the severity of on-going inflammation predicts altered functional brain connectivity in people with rheumatoid arthritis.

Andrew Schrepf
Chelsea M. Kaplan
Neil Basu
ResearchOpen Access08 Jun 2018
Nature Communications

Volume: 9, P: 1-11
Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disorder characterised by asthma, eosinophilia and vasculitis. Here, the authors describe a genome-wide association study of EGPA that reveals clinical and genetic differences between subgroups stratified by autoantibody status (ANCA).

Paul A Lyons
James E Peters
Kenneth G. C. Smith
ResearchOpen Access12 Nov 2019
Nature Communications

Volume: 10, P: 1-13
A multisystem, cardio-renal investigation of post-COVID-19 illness

Deep clinical phenotyping at 28–60 days post-discharge of patients who had been hospitalized with COVID-19 and subsequent long-term follow-up with electronic health records reveal evidence of persistent cardio-renal involvement.

Andrew J. Morrow
Robert Sykes
Colin Berry
ResearchOpen Access23 May 2022
Nature Medicine

Volume: 28, P: 1303-1313
Reply to 'Nitrite–methemoglobin inadequate for hypoxic vasodilation'

Bradley I. Goetz
Pamela Wang
Daniel B. Kim-Shapiro
Correspondence01 Jun 2009
Nature Chemical Biology

Volume: 5, P: 367
Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS—A multicentre case–control study

Rajish S. K. Shil
Adam Seed
Hannah Stark
ResearchOpen Access27 Jan 2025
Scientific Reports

Volume: 15, P: 1-14
Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center

Jim Aitken
Karen Ambrose
Rachel Zillwood
Amendments and Corrections17 Jul 2020
Nature Biotechnology

Volume: 38, P: 1000
Large-vessel vasculitis

Large-vessel vasculitis is the most common primary vasculitis in adults, manifesting as inflammation of the aorta and its major branches. This Primer reviews the epidemiology, pathophysiology, diagnosis and management of this disease, highlights its effects on patient quality of life, and discusses future research questions.

Dan Pugh
Maira Karabayas
Neeraj Dhaun
Reviews06 Jan 2022
Nature Reviews Disease Primers

Volume: 7, P: 1-23
Enabling data linkages for rare diseases in a resilient environment with the SERDIF framework

Albert Navarro-Gallinad
Fabrizio Orlandi
Declan O’Sullivan
ResearchOpen Access04 Oct 2024
npj Digital Medicine

Volume: 7, P: 1-9
Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics

Max Lam
Chia-Yen Chen
Todd Lencz
ResearchOpen Access25 May 2021
Neuropsychopharmacology

Volume: 46, P: 1788-1801
Immune mechanisms of depression in rheumatoid arthritis

Depression is a common comorbidity in rheumatoid arthritis, and shared immune mechanisms link the two conditions. This Review explores potential peripheral and central interactions between the immune system and brain, the understanding of which could aid in the development of novel therapeutics.

James Brock
Neil Basu
Jonathan Cavanagh
Reviews03 Nov 2023
Nature Reviews Rheumatology

Volume: 19, P: 790-804
Interaction of the pRB-family proteins with factors containing paired-like homeodomains

O'Neil Wiggan
Aiko Taniguchi-Sidle
Paul A Hamel
Research23 Jan 1998
Oncogene

Volume: 16, P: 227-236
ANCA-associated vasculitis

The anti-neutrophil cytoplasmic antibody-associated vasculitides (AAVs) are autoimmune disorders characterized by inflammation and destruction of small blood vessels. In this Primer, the authors discuss the classification of AAVs and the pathogenetic mechanisms, diagnosis and treatment of these debilitating conditions.

A. Richard Kitching
Hans-Joachim Anders
Renate Kain
Reviews27 Aug 2020
Nature Reviews Disease Primers

Volume: 6, P: 1-27
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort

Francesca L. Beaudoin
Xinming An
Samuel A. McLean
ResearchOpen Access07 Jan 2023
Translational Psychiatry

Volume: 13, P: 1-11
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

Malcolm G Dunlop
Sara E Dobbins
Richard S Houlston
Research27 May 2012
Nature Genetics

Volume: 44, P: 770-776
Scalable and robust SARS-CoV-2 testing in an academic center

Jim Aitken
Karen Ambrose
Rachel Zillwood
Correspondence18 Jun 2020
Nature Biotechnology

Volume: 38, P: 927-931
Robust estimation of bacterial cell count from optical density

In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.

Jacob Beal
Natalie G. Farny
Jiajie Zhou
ResearchOpen Access17 Sept 2020
Communications Biology

Volume: 3, P: 1-29
Author Correction: Robust estimation of bacterial cell count from optical density

Jacob Beal
Natalie G. Farny
Jiajie Zhou
Amendments and CorrectionsOpen Access27 Oct 2020
Communications Biology

Volume: 3, P: 1

Search

Local structural flexibility drives oligomorphism in computationally designed protein assemblies

Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction

The quest for targetable pain mechanisms in 2024

¹⁸F-FDG-PET/MR imaging to monitor disease activity in large vessel vasculitis

The characterization of Klebsiella pneumoniae associated with neonatal sepsis in low- and middle-income countries to inform vaccine design

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Developmental Differences of Cystic Fibrosis Transmembrane Conductance Regulator Functional Expression in Isolated Rat Fetal Distal Airway Epithelial Cells

RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage

SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease

Fatty acid transport protein 2 reprograms neutrophils in cancer

Design of target specific peptide inhibitors using generative deep learning and molecular dynamics simulations

Catalytic generation of N₂O₃ by the concerted nitrite reductase and anhydrase activity of hemoglobin

Hypothetical model ignores many important pathophysiologic mechanisms in fibromyalgia

Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Hospital contribution to variation in rates of vaginal birth after cesarean

A multi-modal MRI study of the central response to inflammation in rheumatoid arthritis

Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status

A multisystem, cardio-renal investigation of post-COVID-19 illness

Reply to 'Nitrite–methemoglobin inadequate for hypoxic vasodilation'

Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS—A multicentre case–control study

Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center

Large-vessel vasculitis

Enabling data linkages for rare diseases in a resilient environment with the SERDIF framework

Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics

Immune mechanisms of depression in rheumatoid arthritis

Interaction of the pRB-family proteins with factors containing paired-like homeodomains

ANCA-associated vasculitis

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Scalable and robust SARS-CoV-2 testing in an academic center

Robust estimation of bacterial cell count from optical density

Author Correction: Robust estimation of bacterial cell count from optical density

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