Nature Search

Alzheimer’s disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production

Clinical trials of γ-secretase inhibitors to treat Alzheimer’s disease show that side effects occur from their non-selective action. Dimitrov et al.show that improved second generation γ-secretase modulators spare cleavage sites of substrate proteins that are implicated in the side effects.

Mitko Dimitrov
Jean-René Alattia
Patrick C. Fraering
Research02 Aug 2013
Nature Communications

Volume: 4, P: 1-10
A delay in vesicle endocytosis by a C-terminal fragment of N-cadherin enhances Aβ synaptotoxicity

Zenghui Teng
Georgia-Ioanna Kartalou
Kurt Gottmann
ResearchOpen Access08 Dec 2023
Cell Death Discovery

Volume: 9, P: 1-9
Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

Notch signalling is involved in prostate cancer progression and therapeutic resistance. Here, the authors show that loss of PTEN in prostate cancer models results in increased Notch1 cleavage and activation through CUX1-mediated transactivation of ADAM17.

Ajinkya Revandkar
Maria Luna Perciato
Andrea Alimonti
ResearchOpen Access12 Dec 2016
Nature Communications

Volume: 7, P: 1-12
Substrate-targeting γ-secretase modulators

Thomas L. Kukar
Thomas B. Ladd
Todd E. Golde
Research12 Jun 2008
Nature

Volume: 453, P: 925-929
Shedding of neurexin 3β ectodomain by ADAM10 releases a soluble fragment that affects the development of newborn neurons

Erika Borcel
Magda Palczynska
Patrick C. Fraering
ResearchOpen Access19 Dec 2016
Scientific Reports

Volume: 6, P: 1-12
The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer’s disease amyloid-β peptides

Xiling Lei
Jing Yu
Fang Wu
ResearchOpen Access16 Nov 2015
Scientific Reports

Volume: 5, P: 1-11

Quick links

Search

Filter By:

Alzheimer’s disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production

A delay in vesicle endocytosis by a C-terminal fragment of N-cadherin enhances Aβ synaptotoxicity

Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

Substrate-targeting γ-secretase modulators

Shedding of neurexin 3β ectodomain by ADAM10 releases a soluble fragment that affects the development of newborn neurons

The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer’s disease amyloid-β peptides

Search

Quick links