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IKKε and TBK1 prevent RIPK1 dependent and independent inflammation

TBK1 and IKKε are involved in the regulation of a range of cellular and inflammatory processes. Here Eren and colleagues discern a role for IKKε in preventing RIPK1-dependent and RIPK1-independent inflammation in mice lacking TBK1 kinase activity.

Remzi Onur Eren
Göksu Gökberk Kaya
Manolis Pasparakis
ResearchOpen Access02 Jan 2024
Nature Communications

Volume: 15, P: 1-18
Publisher Correction: Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

Huipeng Jiao
Laurens Wachsmuth
Manolis Pasparakis
Amendments and Corrections03 Apr 2020
Nature

Volume: 580, P: E10
Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes

Mitochondria have a pivotal role in the transport of dietary lipids in enterocytes, a finding that might have relevance to understanding the aberrant gastrointestinal function in patients with mitochondrial disorders.

Chrysanthi Moschandrea
Vangelis Kondylis
Manolis Pasparakis
ResearchOpen Access20 Dec 2023
Nature

Volume: 625, P: 385-392
Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation

Receptor interacting protein kinase 1 (RIPK1) regulates cell death and inflammatory responses. Here the authors show that autophosphorylation at Ser166 is required for RIPK1-mediated cell death and inflammation in mouse models of inflammatory pathologies, making Ser166 phosphorylation a possible biomarker for RIPK1-mediated inflammatory diseases.

Lucie Laurien
Masahiro Nagata
Manolis Pasparakis
ResearchOpen Access08 Apr 2020
Nature Communications

Volume: 11, P: 1-16
Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

The enzymatic activity of caspase-8 controls apoptosis, necroptosis and pyroptosis, and prevents tissue damage during embryonic development and adulthood in mice.

Melanie Fritsch
Saskia D. Günther
Hamid Kashkar
Research20 Nov 2019
Nature

Volume: 575, P: 683-687
A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism

Despite widespread transcription of LncRNA in mammalian systems, their contribution to metabolic homeostasis at the cellular and tissue level remains elusive. Here Pradas-Juni et al. describe a transcription factor–LncRNA pathway that couples hepatocyte nutrient sensing to regulation of glucose metabolism in mice.

Marta Pradas-Juni
Nils R. Hansmeier
Jan-Wilhelm Kornfeld
ResearchOpen Access31 Jan 2020
Nature Communications

Volume: 11, P: 1-17
Lipid signalling drives proteolytic rewiring of mitochondria by YME1L

Under conditions such as hypoxia or starvation, an mTORC1-lipid signalling pathway initiates mitochondrial proteolysis by YME1L.

Thomas MacVicar
Yohsuke Ohba
Thomas Langer
Research06 Nov 2019
Nature

Volume: 575, P: 361-365
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

Analyses of mouse models of inflammation suggest some chronic inflammatory conditions may result from Z-DNA-binding protein 1 sensing endogenous Z-form nucleic acids—such as those of endogenous retroelements—through its Zα domains.

Huipeng Jiao
Laurens Wachsmuth
Manolis Pasparakis
Research25 Mar 2020
Nature

Volume: 580, P: 391-395
ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis

Lioba Koerner
Laurens Wachsmuth
Manolis Pasparakis
ResearchOpen Access07 Jun 2024
Cell Death & Differentiation

Volume: 31, P: 938-953

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