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Liver X receptor unlinks intestinal regeneration and tumorigenesis

Liver X receptor drives epithelial Areg-mediated intestinal regeneration, while preventing tumour growth through adaptive immune responses.

Srustidhar Das
S. Martina Parigi
Eduardo J. Villablanca
ResearchOpen Access20 Nov 2024
Nature

Volume: 637, P: 1198-1206
Turbinate-homing IgA-secreting cells originate in the nasal lymphoid tissues

Nasal vaccination induces B cell expansion in the nasal-associated lymphoid tissues, followed by homing to the nasal turbinates and glandular acinar structures.

Jingjing Liu
Liat Stoler-Barak
Ziv Shulman
Research31 Jul 2024
Nature

Volume: 632, P: 637-646
Anti-tumour immunity induces aberrant peptide presentation in melanoma

Tryptophan depletion in melanoma cells after prolonged treatment with interferon-γ (IFNγ) results in ribosomal frameshifting and the production of aberrant peptides that can be presented to T cells and induce an immune response.

Osnat Bartok
Abhijeet Pataskar
Reuven Agami
Research16 Dec 2020
Nature

Volume: 590, P: 332-337