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Nature Immunology (1)

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IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs

Adoro and colleagues report the involvement of the IRE1α–XBP1 signaling axis in protecting hematopoietic stem and progenitor cells from proteomic stress and as a safeguard against leukemic transformation.

Brendan M. Barton
Francheska Son
Stanley Adoro
Research09 Jan 2025
Nature Immunology

Volume: 26, P: 200-214

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IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs

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