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Showing 1–4 of 4 results
Advanced filters: Author: Stephane Chappaz Clear advanced filters

  • A phenotypic screen led to the identification of potent inhibitors of mouse BAK-driven apoptosis. The compounds interact with VDAC2 and stabilize its interaction with BAK, blocking apoptosis at an early stage to preserve long-term cell survival.

    • Mark F. van Delft
    • Stephane Chappaz
    • Benjamin T. Kile
    Research
    Nature Chemical Biology
    Volume: 15, P: 1057-1066

  • An engineered Pichia pastoris strain enables the synthesis of tryptophan C-mannosylated proteins, and selected monoclonal antibodies provide tools for detecting these modified proteins and studying their functions.

    • Alan John
    • Michael A. JärvÃ¥
    • Ethan D. Goddard-Borger
    Research
    Nature Chemical Biology
    Volume: 17, P: 428-437

  • BAX and BAK are pro-apoptotic proteins whose activity is essential for the action of many anti-cancer drugs and to suppress tumorigenesis. Here, the authors perform a genome-wide CRISPR/Cas9 screen and identify VDAC2 as a promoter of BAX-mediated apoptosis that is important for an efficient chemotherapeutic response and to suppress tumor formation.

    • Hui San Chin
    • Mark X. Li
    • Grant Dewson
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13