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Showing 1–4 of 4 results
Advanced filters: Author: Sukrit Singh Clear advanced filters

  • Many viral proteins are thought to be unlikely candidates for drug discovery as they lack obvious drug binding sites. Here, the authors use computational approaches followed by experimental validation to identify a cryptic pocket within the Ebola virus protein VP35.

    • Matthew A. Cruz
    • Thomas E. Frederick
    • Gregory R. Bowman
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • Somatic mutations in MEN1 are identified in patients with leukaemia treated with a novel chromatin-targeting therapy, and the mechanism by which these mutations mediate therapeutic resistance is characterized.

    • Florian Perner
    • Eytan M. Stein
    • Sheng F. Cai
    Research
    Nature
    Volume: 615, P: 913-919

  • Simulations of the SARS-CoV-2 proteome that include over 0.1 s of aggregate data are reported. Spike opening was observed, revealing cryptic epitopes that differ between variants, explaining differential interactions with antibodies and receptors that determine pathogenicity. The cryptic pockets described provide new targets for antivirals and a wealth of mechanistic insight.

    • Maxwell I. Zimmerman
    • Justin R. Porter
    • Gregory R. Bowman
    Research
    Nature Chemistry
    Volume: 13, P: 651-659

  • SARS-CoV-2 nucleocapsid (N) protein is responsible for viral genome packaging. Here the authors employ single-molecule spectroscopy with all-atom simulations to provide the molecular details of N protein and show that it undergoes phase separation with RNA.

    • Jasmine Cubuk
    • Jhullian J. Alston
    • Alex S. Holehouse
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17