Nature Search

Genetic predictors of educational attainment and intelligence test performance predict voter turnout

The genetic variance that predicts educational attainment or intelligence test performance predicts individual-level voter turnout in a nationally representative sample and among people with psychiatric conditions, such as depression.

Lene Aarøe
Vivek Appadurai
Michael Bang Petersen
Research09 Nov 2020
Nature Human Behaviour

Volume: 5, P: 281-291
A saturated map of common genetic variants associated with human height

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Loïc Yengo
Sailaja Vedantam
Joel N. Hirschhorn
ResearchOpen Access12 Oct 2022
Nature

Volume: 610, P: 704-712
Population genomics of post-glacial western Eurasia

An analysis involving the shotgun sequencing of more than 300 ancient genomes from Eurasia reveals a deep east–west genetic divide from the Black Sea to the Baltic, and provides insight into the distinct effects of the Neolithic transition on either side of this boundary.

Morten E. Allentoft
Martin Sikora
Eske Willerslev
ResearchOpen Access10 Jan 2024
Nature

Volume: 625, P: 301-311
Phenotype integration improves power and preserves specificity in biobank-based genetic studies of major depressive disorder

Phenotype imputation increases the effective sample size of major depressive disorder cases in UK Biobank, enhancing study power and polygenic risk score (PRS) accuracy. A new pleiotropy metric enables assessment of PRS specificity and comparison among different PRS models.

Andrew Dahl
Michael Thompson
Na Cai
ResearchOpen Access20 Nov 2023
Nature Genetics

Volume: 55, P: 2082-2093
Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study

Annette Erlangsen
Vivek Appadurai
Esben Agerbo
Research16 Aug 2018
Molecular Psychiatry

Volume: 25, P: 2410-2421
Publisher Correction: Population genomics of post-glacial western Eurasia

Morten E. Allentoft
Martin Sikora
Eske Willerslev
Amendments and CorrectionsOpen Access18 Jan 2024
Nature

Volume: 626, P: E3
Polygenic profiles define aspects of clinical heterogeneity in attention deficit hyperactivity disorder

Genome-wide analyses yield insights into the polygenic effects contributing to clinical heterogeneity in attention deficit hyperactivity disorder, advancing understanding of its genetic etiology and serving as a model for future studies in other complex disorders.

Sonja LaBianca
Isabell Brikell
Andrew J. Schork
Research30 Nov 2023
Nature Genetics

Volume: 56, P: 234-244
Accuracy of haplotype estimation and whole genome imputation affects complex trait analyses in complex biobanks

An analysis of phasing and imputation performances using iPSYCH consortium data across multiple methods and data integration protocols provides a useful framework in designing workflows to construct next-generation biobanks or conduct biobank-scale analyses.

Vivek Appadurai
Jonas Bybjerg-Grauholm
Andrew J. Schork
ResearchOpen Access26 Jan 2023
Communications Biology

Volume: 6, P: 1-12
Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration

Gestational duration depends on both maternal and fetal genetic influences. Here, the authors perform a fetal genome-wide association meta-analysis and find that a locus on 2q13 is associated with pregnancy duration and further show that the lead SNP rs7594852 changes the binding properties of transcriptional repressor HIC1.

Xueping Liu
Dorte Helenius
Bjarke Feenstra
ResearchOpen Access02 Sept 2019
Nature Communications

Volume: 10, P: 1-13
Spatial fine-mapping for gene-by-environment effects identifies risk hot spots for schizophrenia

Schizophrenia (SCZ) risk is influenced by genetic and environmental factors. Here, the authors develop a statistical method for analyzing gene-by-environment effects in SCZ risk across Denmark with fine spatial resolution.

Chun Chieh Fan
John J. McGrath
Carsten Bøcker Pedersen
ResearchOpen Access13 Dec 2018
Nature Communications

Volume: 9, P: 1-7
A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment

Schork et al. identify novel variants contributing to shared risk among psychiatric disorders and suggest that these variants act through the disruption of early neurodevelopment.

Andrew J. Schork
Hyejung Won
Thomas Werge
Research28 Jan 2019
Nature Neuroscience

Volume: 22, P: 353-361
Analysis of exonic deletions in a large population study provides novel insights into NRXN1 pathology

Simone Montalbano
Morten Dybdahl Krebs
Andrés Ingason
ResearchOpen Access19 Dec 2024
npj Genomic Medicine

Volume: 9, P: 1-10
Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity

Veera M. Rajagopal
Andrea Ganna
Ditte Demontis
ResearchOpen Access09 Jan 2023
Scientific Reports

Volume: 13, P: 1-16
A large-scale genomic investigation of susceptibility to infection and its association with mental disorders in the Danish population

Ron Nudel
Yunpeng Wang
Michael E. Benros
ResearchOpen Access11 Nov 2019
Translational Psychiatry

Volume: 9, P: 1-10

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