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DNA Damage Regulated Autophagy Modulator 1 (DRAM1) plays pivotal roles in autophagy regulation. Here, the authors show that DRAM1 stabilizes lysosomal VAMP8, thereby promoting autolysosome maturation. Furthermore, they establish that DRAM1–VAMP8 axis enhances autophagic flux and facilitates hepatocellular carcinoma extravasation, as validated in both zebrafish xenograft and mouse metastatic models.

The function and regulatory mechanism of mRNA acetylation modification in cancer progression remains largely unknown. Here the authors identify that targeting tumor N4-acetylcytidine (ac4C) RNA acetyltransferase NAT10 improves anti-tumor response via MYC/CDK2/DNMT1/dsRNA/type I IFN pathway, and show the synergic anti-tumor effect of NAT10 inhibition with aPD-1.

Steroid resistant asthma can be combatted with antibody therapy, but delivery and off-target effects are a concern. Here, the authors report on the co-delivery of thymic stromal lymphopoietin nanobody mRNA and budesonide in budesonide-incorporated inhalable lipid nanoparticles to treat steroid resistant asthma.

Authors report an oblique photothermal microscope system for ultrasensitive infrared spectroscopic imaging of live subjects at sub-micron resolutions. The method enables low-dose skin imaging without photodamage, and is a highly sensitive platform for in vivo and in situ molecular analysis.

Fan et al. show that cTAGE5 is essential for adipogenesis and adipose tissue development. Mechanistically, cTAGE5 promotes pro-insulin receptor processing, which mediates actin cytoskeleton remodeling and lipolysis during the adipocyte differentiation.

Lampreys are jawless vertebrates that can offer unique insights into vertebrate evolution. Here they generate a comprehensive cell atlas of the lamprey, uncovering 70 distinct cell types across 14 tissues, and identify pancreas-like cells in the lamprey small intestine.

The isolation of a crystalline radical cation carbon(I) species, generated via single-electron transfer between a carbodicarbene and a nitroaromatic compound, is reported. The resulting radical ion pair can mediate various C–O and C–C cross-coupling reactions with electron-deficient arenes bearing a leaving group.

Lan et al. demonstrate the high performance of plasma p-tau217 in detecting and tracking multiple aspects of Alzheimer’s disease pathology, outperforming other plasma tau biomarkers across two Chinese cohorts (GHABS and Huashan) and the North American ADNI cohort.

Iacobucci et al. present the single-cell transcriptomic profile of patients with B cell acute lymphoblastic leukemia, report enriched multipotency and develop a multipotency score that is associated with worse survival in pediatric patients.

The authors demonstrate that the response of the flexural vibrations of twisted bilayer graphene can be hysteretic depending on the angle between the lattices of the layers, finding that the quality factors of the vibrations are enhanced compared to untwisted bilayers.

Here the authors uncover an epigenetic mechanism regulating pancreatic β-cell adaptation during pregnancy in mice involving ACSS2 and STAT3 coordinated histone acetylation. These findings provide clues into gestational diabetes mechanisms and potential therapeutic targets.

The RNA binding protein hnRNPL is recruited to chromatin by the PIK3CB promoter-transcribed non-coding RNA and forms phase-separated condensates, which activates PIK3CB transcription and glycolysis, thus promoting ovarian cancer progression.

Dihydroxyacid dehydratase (DHAD) is an essential enzyme for the synthesis of branched-chain amino acids in plants. Here, the authors rationally design a range of DHAD inhibitors as herbicides and present the crystal structure of a lead compound in complex with Arabidopsis DHAD.

High mobility group A1 (HMGA1) has been identified to play a role in tumour progression but its involvement in anti-tumour immunity of esophagael squamous cell carcinoma (ESCC) remains unclear. Here the authors report that the inhibition of STING-mediated anti-tumour immunity by HMGA1 results in promotion of ESCC tumorigenesis.

The authors use nitrogen-vacancy centre magnetometry to explore layer number and magnetic field evolution of ferromagnetic and antiferromagnetic domains in the A-type antiferromagnet CrPS₄.

This work reveals an unusual T⁴ temperature dependence of the electronic thermal conductivity at ultralow temperatures and a strong violation of the Wiedemann-Franz law in the topological compensated semimetals TaAs₂, NbAs₂, and NdSb.

Enantiocontrolled transformation of carbenium ions is challenging due to their instability and high reactivity. Now, combining a chiral organocatalyst with a photocatalyst enables enantioselective intramolecular amidation of C(sp³)–H bonds to afford chiral oxazolidine products via a transient carbenium ion complex.

The gut microbiota bacterium Ruminococcus gnavus is implicated in the development of cirrhotic liver encephalopathy through the production of neurotoxins.

Diabetic peripheral neuropathy (DPN) is associated with immunometabolic stress, but the underlying molecular mechanisms remain unclear. Here the authors use single-cell atlas of human peripheral nerve and data from diabetic mouse models to implicate altered GLUT3, ERK and mTOR signaling and downstream dysregulated mast cell activation in DPN progression.

Gene regulatory networks are crucial for understanding complex gene regulation in plants and could advance crop improvement for more sustainable and climate-resilient agricultural practices.

A soft mesh microelectrode array can seamlessly integrate in developing brains, enabling long-term, stable mapping of how single-neuron activity and population dynamics emerge and evolve during brain development.

Aberrant activation of autoreactive T cells is a hallmark of autoimmune diseases. Here, by analysing CD4 T cells from patients with polymyositis and mice with experimental autoimmune myositis, the authors show that TIGIT limits the differentiation of inflammatory Th1 and Th17 cells via a metabolic-epigenetic mechanism, which involves the inhibition of CD28-mediated PI3K/AKT/mTOR costimulatory signaling.

Transcriptome-wide m⁶A RNA methylation profile in 162 primary prostate tumors identifies m⁶A association with prognostic clinical features and disease aggression.

A facile light-triggered doping strategy involving a series of inactive photoactivable dopants is described that facilitates tunable regionally controlled n-doping of organic semiconductors, resulting in stable patterning of the doping profile at record high resolutions.

A novel covalent inhibitor, ISM3312, targets the main protease of multiple human coronaviruses, including drug-resistant strains, and shows broad antiviral activity. It offers a promising therapeutic strategy against current and future coronavirus threats.

Although germanium shares similar chemical properties with silicon, synthesizing chiral germanium centers has proven significantly more challenging. Here, the authors use deborylative alkylation of germanium chlorides and copper-catalyzed diol desymmetrization to transform simple germanium tetrachloride into a chiral germanium center in four steps.

Allenes are versatile substrates in synthetic chemistry. Now an iron catalyst enables unusual regioselectivity by mediating an electrophilicity reversal of allenes for stereoselective alkenylzincation reactions affording 1,4-diene zinc products.

C−H bond functionalization is widely used in chemical synthesis but achieving regio- and stereoselectivity is still challenging. Here, the authors report the mechanism of three Fe(II)/α-ketoglutarate-dependent dioxygenases in bicyclomycin synthesis, which depicts the natural strategy to sequentially hydroxylate specific C–H bonds of similar substrates (cyclodipeptides)

The cascade reaction of lipopolysaccharides (LPS), cell-free DNA (cfDNA), and reactive oxygen species (ROS), drives the development of inflammatory bowel disease (IBD). Here, Xu et. al. construct chiral nanomedicines composed of four functional moieties to eliminate LPS, ROS, and cfDNA for targeted treatment of IBD.

Abnormal T cell proliferation often triggers autoimmune disorders. Here the authors show that T cell-specific deficiency of the enzyme N-acetyltransferase 10 ameliorates experimental autoimmune encephalitis potentially by RACK1-mediated regulation of T cell metabolism and expansion.

Spatial transcriptomics (ST) enables biological findings within tissue context, but analyzing increasingly large ST data remains challenging. Here, authors introduce HERGAST, a system that can identify fine-scale spatial structures and amplifies gene expression signals in ultra-large-scale ST data.

CNS injuries cause persistent deficits. Here, the authors show that regenerated axons in an optic tract injury model form functional synapses, restoring the pupillary light reflex, and highlight neuronal types and presynaptic activity in recovery.

Accurate detection of nostril airflow is vital for real-time respiratory monitoring, however, existing methods can only detect a single stimulus of nostril airflow. This report describes a crosslinked eutectogel for simultaneous and independent sensing of pressure and temperature for the nostril airflow.

Gain-of-function mutations in CTNNB1 (encoding for b-catenin) leading to deregulated Wnt/β-catenin signaling are frequently observed in patients with hepatocellular carcinoma (HCC). Here the authors show that inhibiting b-catenin with lipid nanoparticles encapsulating siRNA targeting CTNNB1 impairs tumor growth and promotes anti-tumor immunity in preclinical HCC models.

Here, the authors performed plasma proteomics and metabolomics analysis and identify the vinculin (VCL) pathway as a key mediator of lung exudation in SARS-CoV-2 infections, particularly associated with Omicron infection. In a mouse model of infection inhibition of VCL leads to reduced lung pathology.

Focal cortical dysplasia type II causes epileptic seizures and is associated with various types of neuronal abnormalities. This study uses patient tissue transcriptomics and animal models to reveal that vascular malformations are a key part of the pathology by creating ischemic-hypoxic microenvironments.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.