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Protonic ceramic electrochemical cells (PCECs) interconvert hydrogen and electricity and therefore have potential as long-duration energy storage systems, but the durability of these devices under industrially relevant conditions is limited. Here the authors report a PCEC that maintains low degradation rates throughout exceptionally long-term durability tests.

Meng et al. demonstrate that RIOK1 phase separation leads to PTEN mRNA sequestration and pentose pathway activation resolving cellular stress in hepatocellular carcinoma. Targeting RIOK1 enhances response to tyrosine kinase inhibitors.

Organic afterglow materials have garnered significant attention in recent years but developing long-lasting, highefficiency, full-color small molecule afterglow systems which can be easily processed remain challenging. Here the authors design a processable molecular glass and employ it as a host in a host-guest strategy to address these challenges.

The red fluorescent protein mScarlet3-H is bright, photostable and very robust to high temperature, chaotropic conditions and oxidative environments. mScarlet3-H works well in correlative light and electron microscopy, tissue clearing and time-lapse super-resolution microscopy.

The molecular characterisation of soft tissue sarcomas (STSs) across diverse populations remains crucial. Here, the authors perform a proteomics and phosphoproteomics analysis of 272 Chinese STS patients across 12 subtypes, and obtain insights related to progression, metastasis, and immune signatures.

Succinylation, a posttranslational modification on lysine residues, is involved in tumor progression. Here, authors show that PDHA1 K83 succinylation is involved in cholangiocarcinoma tumorigenesis through regulation of macrophage antigen presentation in the tumor microenvironment

NCOMMS-24-44031B Nanozymes have found wide applications in various fields, but the deviation between the working and optimal pHs of nanozymes limits their practical applications. Here, the authors report a strategy to modulate the microenvironmental pHs of metal–organic framework nanozymes, enabling them to exhibit optimal activity under neutral pH conditions.

SCUBA-D is a denoising diffusion probabilistic model that can perform a variety of protein backbone design tasks, including generation of backbones from random noise, from user-sketched designs, and backbones to scaffold predefined motifs that can bind small molecules or other proteins.

Here the authors analyzed 3.7 petavoxels of 3D imaging data from 204 mouse brains, aiming to comprehensively characterize diverse morphological and modular patterns conserved across six spatial scales of mouse brain anatomy, ranging from the whole-brain scale to synaptic levels.

A two-step, video-based deep learning model is developed to first screen for cardiac anomalies using noncontrast magnetic resonance imaging, followed by diagnosis of 11 types of cardiovascular disease using gadolinium enhancement-based imaging.

Despite great success in generation of ultralong organic phosphorescence (UOP) by suppressing non-radiative transitions through attractive interactions, consideration of repulsive interactions on UOP remains largely unexplored. Here, the authors introduce carboxyl groups into organic phosphors, enabling formation of the intense repulsive interactions between the isolated molecules and the matrix in rigid environment.

Preparing triangulene-based high spin structures is of interest for molecular spintronics. Here, the authors generate high spin triangulene trimers on Au(111) via a surface-assisted dehydration reaction.

The authors identify one emerging H2N2 AIV, reveal the molecular basis of human-type receptor binding of the H2N2 AIV and pandemic strains, and evaluate the public risk of H2N2 AIV by its infection, transmission and mammalian-adaptation features.

Here the authors discover that furanodienone (FDN), a small molecule derived from ginger, exhibits PXR agonist activity selective for the intestine and show that when FDN is administered orally in pharmacological doses ameliorates induced colitis in male mice.

Fu et al. describe a pathogen effector, HaRxL10 that suppresses plant immunity and interferes with plant development by hijacking the clock component CHE to perturb its function in transcriptional regulation.

The relevance of spliceosome core components in cancer is less understood. Here the authors show SmD2, a core component of the spliceosome machinery, is under acetylation-dependent regulation, which could be targeted to enhance sensitivity to PARP inhibitors in hepatocellular carcinoma.

Experimental evidence for charge coupling to ferroelectric soft mode is scarce. Here, the authors find a photogenerated coherent phonon coupling to the electronic transition above the bandgap in the van der Waals ferroelectric semiconductor NbOI2.

A key challenge in robotics is leveraging pre-training as a form of knowledge to generate movements. The authors propose a general learning framework for reusing pre-trained knowledge across different perception and task levels. The deployed robots exhibit lifelike agility and sophisticated game-playing strategies.

A deep learning method for protein sequence design on given backbones, ABACUS-R, is proposed in this study. ABACUS-R shows an improved performance when compared with conventional energy function-based methods in wet experiments.

Free-standing nitrogen-doped amorphous monolayer carbon consisting of mixed five-, six- and seven-membered rings was prepared through the polymerization of pyrrole within the confined interlayer cavity of a removable layered-double-hydroxide template.

Epstein-Barr virus (EBV) is associated with high risk for nasopharyngeal carcinoma (NPC). Here, the authors develop a comprehensive risk score that combines risk effects of EBV and human genetics for NPC risk stratification.

SPARK Taiwan has strengthened the country’s biotech sector, encouraged scientists to start businesses and fostered cross-disciplinary collaboration.

The hypersensitivity of sulfide solid-state electrolytes to moisture are not compatible with today’s manufacturing infrastructure. Here, authors present a reversible surface modification strategy using 1-undecanethiol, that enables the processability of sulfide SSEs under humid ambient air.

The SARS-CoV-2 Omicron variant spreads rapidly. Here the authors show that Omicron S preferentially adopts the one-RBD-up conformation, which leads to a non-RBM-binding monoclonal antibody escape. Mutagenesis reveals that S371L, S373P and S375F substitutions enhance the conformational stability.

Indica rice has higher nitrate assimilation and nitrogen use efficiency (NUE) than japonica rice, but the mechanism is unclear. Here, the authors reveal that the difference is partly due to allelic variation of a nitrate reductase encoding gene and this indica allele can increase yield potential and NUE.

SARS-CoV-2 Omicron variant evolves into multiple sub-variants. Here, authors evaluate the binding capacity of these sub-variants to human and animal ACE2s and reveal molecular bases for their receptor binding and broader interspecies recognition.

The DAWN study is a phase 3 clinical trial that demonstrates effective glycemic control of dorzagliatin as an add-on therapy to metfomin in patients with type 2 diabetes.

Novel strategies are needed to overcome chemotherapy resistance. Here the authors report chemotherapy induces the phosphorylation of Lysyl oxidase-like 3, which in turn stabilizes dihydroorotate dehydrogenase (DHODH) and that DHODH inhibitor sensitizes tumor cells to oxaliplatin treatment by inducing ferroptosis in liver cancer.

Here, the authors demonstrate the application of machine learning to optimize the device fabrication process for wafer-scale 2D semiconductors, and eventually fabricate digital, analog, and optoelectrical circuits.

Using metagenomics sequencing, Zhang et al. examined sex- and age-dependent trajectories of the gut microbiota in four cohorts across China, Israel and the Netherlands. The authors found age-related gut microbial trajectories common across all populations, with the abundance of Streptococcus gordonii predicting chronological age.

A wearable microgrid powered solely by fingertip perspiration can monitor metabolic biomarkers over extended periods of time.

A multidisciplinary approach, including genetics and behavioural assays, identifies a single gene, CYP4PC1, which integrates both sex differentiation and hormone signalling with sexual attractiveness in the German cockroach.

Raised serum urate levels are a risk factor for gout, a common form of inflammatory arthritis. Here Li et al.conduct a multistage genome-wide association study in a Han Chinese population and identify three novel loci likely associated with the progression from hyperuricemia to gout.

Saikogenin A ameliorates ethanol-induced cellular damage likely by binding to the SIRT1 protein, activating PPAR-α and suppressing mTOR activity.

Surface condensation is predetermined and is typically adjusted by chemical or topographical surface modification. Here, the authors report on a strategy to control the surface condensation behavior by adjusting molecular conformations in self-assembled monolayers.