Search

Here, the authors use computational screening and a chemogenetic analysis of transgenic mice to show that Gα_s-coupled G-protein-coupled receptors on exhausted CD8⁺ T cells are involved in suppression of effector functions and inhibition of the protective effects of immune checkpoint immunotherapy.

Grain boundaries in graphene degrade its properties, and large single-crystal graphene is desirable for electronic applications of graphene. Gaoet al. develop a method to produce millimetre-sized hexagonal single-crystal graphene grains, and films composed of the grains, on platinum by chemical vapour deposition.

Bats account for 20 per cent of all mammals, these are the only mammals with powered flight, and are among the few animals that echolocate. Here, Seim et al. sequence the genome of the long-lived (>40 years) Brandt’s bat, Myotis brandtiiand provide clues to its evolution, longevity and other traits.

This study analyses radio observations of the jet in galaxy M87, from which the existence of a spinning black hole that induces Lense–Thirring precession of a misaligned accretion disk is inferred.

Monomethyl auristatin (MMAE), also known for its radiosensitizer properties, is a common antibody drug conjugate used for cancer therapy. Here the authors show that, in combination with radiotherapy, tumor-directed antibodies or peptides conjugated to MMAE promote anti-tumor immune responses, improving response to checkpoint inhibitors in preclinical cancer models.

A significant proportion of individuals with inherited neuromuscular disease do not receive a genetic diagnosis. Here, the authors establish CCG expansions in the 5’ untranslated region of ABCD3 as a cause of oculopharyngodistal myopathy (OPDM) in individuals of European ancestry and identify increased expression of expansion-containing ABCD3 transcripts as a possible disease mechanism underlying muscle degeneration.

Keeping up with the latest variant-related research is vital for genomic medicine. Here we present LitVar 2.0, a significantly improved web-based system to accurately search for genetic variants in the unstructured literature. LitVar 2.0 provides a unified search of full text and supplementary data, and improved variant recognition accuracy.

The conversion of methane to target one-carbon oxygenates relies on a two-step process that is carbon and energy intensive. Direct oxidation offers a sustainable alternative pathway. Here, the authors report on the selective photocatalytic oxidation of methane at room temperature using bismuth vanadate catalyst, realizing high methanol and formaldehyde selectivity.

A recombinant vaccine that targets the receptor-binding ___domain of the spike protein of SARS-CoV-2 induces a potent antibody response in immunized mice, rabbits and non-human primates, and protects primates from infection with the virus.

Sulphate-driven anaerobic oxidation of methane played an important role in removing methane from Lake Pannon, the largest European lake from Miocene to Pliocene, according to sulphur isotope analysis and elemental ratios analysis in Lake Pannon sediments

Tuberculosis (TB) remains one of the world’s deadliest communicable diseases, novel anti-TB agents are urgently needed due to severe drug resistance and the co-epidemic of TB/HIV. Here, the authors show that anti-mycobacterial ilamycin congeners bearing unusual structural units possess extremely potent anti-tuberculosis activities.

Food safety is jeopardized by the global trade in contaminated foods. Huang et al. demonstrate how consumer exposure to the toxic chemical polychlorinated biphenyl-153 (PCB-153) can be modelled and identify regions with high consumer PCB-153 exposure resulting from imported fish consumption.

Cation exchange membranes embedded with MnO₂ nanoparticles form selective outer-sphere complexes with phosphate ions imparting an extremely selective permeation pathway.

The high toxicity of nerve agents makes the development of fluorescence sensors with suitable limit of detection challenging. Here, the authors propose a sensor design based on a conjugated microporous polymer film for the detection of diethyl chlorophosphate, a substitute of Sarin, with low detection limit of 2.5 ppt.

Zirconium phosphonate based metal-organic frameworks often exhibit superior chemical stabilities, but typically exist as poorly crystalline or amorphous materials. Here the authors exploit an ionothermal method to obtain highly porous and remarkably stable single crystalline zirconium phosphonate frameworks that can efficiently remove uranyl ions from aqueous solutions.

Locusts are destructive agricultural pests and serve as a model organism for studies of insects. Here, the authors report a draft genome sequence of the migratory locust, Locusta migratoria, and provide insight into genes associated with key survival traits such as phase-change, long-distance migration and feeding.

TIP60-mediated crotonylation of the microtubule plus-end tracking protein EB1 at Lys66 regulates attachment of astral microtubules to the lateral cell cortex and spindle positioning.

Chemical optimization of arylomycins results in an inhibitor of bacterial type I signal peptidase that shows activity both against multidrug-resistant clinical isolates of Gram-negative bacteria in vitro and in several in vivo infection models.

The performance of enzymatic biofuel cells is greatly hindered by the poor electron transfer between enzyme catalysts and electrode surfaces. Now, an efficient electrical connection is made by coupling conventional direct and mediated electron transfer mechanisms, leading to much improved power density and stability.

The corpus cavernosum is the most important structure for penile erection, and its dysfunction causes physiological and psychological problems. Here the authors perform single-cell RNA-sequencing on corpus cavernosum samples from males with normal erection and erectile dysfunction patients, providing insights into this pathology.

Though flexible microwave integrated circuits (MICs) are desirable for the construction of functional microwave amplifier circuits, realizing low cost III-V-based MMICs remains a challenge. Here, the authors report a heterogeneous integration strategy for the fabrication of flexible low-cost MICs.

A large-scale single-cell transcriptomic atlas of the non-human primate Macaca fascicularis encompasses over 1 million cells from 45 adult tissues.

The blind mole rat (BMR), Spalax galili, is perfectly adapted to life underground. Here, the authors sequence the BMR genome and transcriptome and highlight genomic features that may have played a role in adaptation to extreme underground stressors, such as darkness hypercapnia and hypoxia.

Memristor crossbars with array sizes of up to 128 × 64 cells are capable of analogue vector-matrix multiplication and can be used for signal processing, image compression and convolutional filtering.