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Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development

The choroid plexus (ChP) provides molecular cues for brain development. However, the underlying mechanisms are unclear. This study identifies an apocrine secretion mechanism in the ChP that modulates the CSF protein composition and instructs cortical development.

Ya’el Courtney
Joshua P. Head
Maria K. Lehtinen
ResearchOpen Access28 May 2025
Nature Neuroscience

P: 1-14
New views of Arc, a master regulator of synaptic plasticity

The immediate early gene product Arc has been broadly implicated in synaptic and experience-dependent plasticity. In this perspective, the authors synthesize disparate views of Arc in molecular signaling and its relevance to neurological disorders.

Jason D Shepherd
Mark F Bear
Reviews30 Jan 2011
Nature Neuroscience

Volume: 14, P: 279-284
Temporal morphogen gradient-driven neural induction shapes single expanded neuroepithelium brain organoids with enhanced cortical identity

PSC-brain organoids are typically formed by static medium switches. Here, authors show that a temporal morphogen gradient during neural induction allows the formation of well-specified cortical organoids with a self-organized single neuroepithelium.

Anna Pagliaro
Roxy Finger
Benedetta Artegiani
ResearchOpen Access28 Nov 2023
Nature Communications

Volume: 14, P: 1-16
A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear

The auditory systems of animals that perceive sounds in air are organized so that mechanosensory hair cells located at different positions respond to specific frequencies. Here, Mann et al. find that a gradient of Bmp7 controls the determination of frequency-specific hair cell characteristics in the chick auditory system.

Zoë F. Mann
Benjamin R. Thiede
Matthew W. Kelley
Research20 May 2014
Nature Communications

Volume: 5, P: 1-16
Correlation detection as a general mechanism for multisensory integration

The human brain integrates inputs across multiple sensory streams into a unified percept. Here Parise and Ernst present a model that assesses the correlation, lag and synchrony of multisensory stimuli, and predicts psychophysical performance on multisensory temporal and spatial tasks.

Cesare V. Parise
Marc O. Ernst
ResearchOpen Access06 Jun 2016
Nature Communications

Volume: 7, P: 1-9
Anchoring and synaptic stability of PSD-95 is driven by ephrin-B3

PSD-95 is one of the most abundant proteins at synapses and underlies synapse development and function. Hruska and colleagues show that the synaptic localization and turnover of PSD-95 relies on a direct interaction with the trans-synaptic organizer ephrin-B3, which is negatively regulated by neuronal activity through MAPK-dependent phosphorylation of ephrin-B3.

Martin Hruska
Nathan T Henderson
Matthew B Dalva
Research19 Oct 2015
Nature Neuroscience

Volume: 18, P: 1594-1605
TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus

Epileptic seizures generate aberrant neurogenesis in the adult mouse hippocampal region but how animals cope with abnormal neurogenesis remains unknown. Here the authors show that microglia are activated through TLR9 signaling and that this leads to sustained expression of TNF-α which attenuates induced aberrant neurogenesis.

Taito Matsuda
Naoya Murao
Kinichi Nakashima
ResearchOpen Access09 Mar 2015
Nature Communications

Volume: 6, P: 1-10
Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms

Gradients of the secreted morphogen Sonic Hedgehog (Shh) pattern the neural tube in vertebrates. Cohen et al.quantify Shh signalling in developing mice, and by constructing a computational model of the process, identify mechanisms by which the dynamics of Shh signalling are regulated.

Michael Cohen
Anna Kicheva
James Briscoe
ResearchOpen Access02 Apr 2015
Nature Communications

Volume: 6, P: 1-12
Netrin-1 Derived from the Ventricular Zone, but not the Floor Plate, Directs Hindbrain Commissural Axons to the Ventral Midline

Kenta Yamauchi
Maya Yamazaki
Tatsumi Hirata
ResearchOpen Access20 Sept 2017
Scientific Reports

Volume: 7, P: 1-12
Floor-plate-derived netrin-1 is dispensable for commissural axon guidance

Preventing netrin secretion from floor-plate cells at the midline does not disrupt axonal guidance; commissural axons develop normally and the data suggest that netrin may influence axons locally by promoting growth cone adhesion.

Chloé Dominici
Juan Antonio Moreno-Bravo
Alain Chédotal
Research26 Apr 2017
Nature

Volume: 545, P: 350-354
Neural circuitry engaged by prostaglandins during the sickness syndrome

Acute exposure to a variety of pathogens or inflammatory insults leads to a well-characterized set of responses in the CNS, aimed at promoting the clearance of the infecting agent. In this review, the authors examine the various symptoms of this 'sickness syndrome' and the actions of prostaglandins in linking inflammation with these CNS responses.

Clifford B Saper
Andrej A Romanovsky
Thomas E Scammell
Reviews26 Jul 2012
Nature Neuroscience

Volume: 15, P: 1088-1095
Autism spectrum disorder-like behaviors induced by hyper-glutamatergic NMDA receptor signaling through hypo-serotonergic 5-HT_1A receptor signaling in the prefrontal cortex in mice exposed to prenatal valproic acid

Hitomi Kurahashi
Kazuo Kunisawa
Akihiro Mouri
ResearchOpen Access11 Oct 2024
Neuropsychopharmacology

Volume: 50, P: 739-750
Roles of axon guidance molecules in neuronal wiring in the developing spinal cord

Spinal neural circuits are established through the navigation of multiple types of neuronal axon to their appropriate synaptic targets. Chédotal reviews the cellular and molecular mechanisms that control this complex wiring, incorporating recent discoveries of new guidance factors.

Alain Chédotal
Reviews18 Apr 2019
Nature Reviews Neuroscience

Volume: 20, P: 380-396
“FlashMap” - A Semi-Automatic Tool for Rapid and Accurate Spatial Analysis of Marker Expression in the Subventricular Zone

Stefan Zweifel
Julie Buquet
Olivier Raineteau
ResearchOpen Access31 Oct 2018
Scientific Reports

Volume: 8, P: 1-13

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