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Nature Metabolism (1)

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Metabolic rewiring induced by ranolazine improves melanoma responses to targeted therapy and immunotherapy

In this study, the anti-anginal drug ranolazine is found to sensitize BRAF inhibitor-resistant melanoma to targeted therapy and immunotherapy by rewiring fatty acid oxidation and the methionine salvage pathway.

Marta Redondo-Muñoz
Francisco Javier Rodriguez-Baena
Imanol Arozarena
ResearchOpen Access10 Aug 2023
Nature Metabolism

Volume: 5, P: 1544-1562

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Metabolic rewiring induced by ranolazine improves melanoma responses to targeted therapy and immunotherapy

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