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Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering

Knock-in mice conditionally or constitutively expressing Cas12 variants enable a wide range of ex vivo and in vivo applications requiring multiplexed genome engineering.

Kaiyuan Tang
Liqun Zhou
Sidi Chen
ResearchOpen Access20 Mar 2025
Nature Biomedical Engineering

P: 1-19
In vivo profiling of metastatic double knockouts through CRISPR–Cpf1 screens

Massively parallel Cpf1 array profiling (MCAP) targets genes and gene pairs that are candidate drivers of metastasis in cancer. In vivo profiling of single and double gene knockouts enables quantitative mapping of the genes’ contribution to metastatic phenotypes.

Ryan D. Chow
Guangchuan Wang
Sidi Chen
Research08 Apr 2019
Nature Methods

Volume: 16, P: 405-408

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Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering

In vivo profiling of metastatic double knockouts through CRISPR–Cpf1 screens

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