Search

A framework is presented to extrapolate the range of behaviors for influenza antibodies. Using this basis set of behaviors, the collective action of multiple antibodies can be teased apart to describe the individual antibodies within.

The authors found, after analyzing 10,960 individuals from 9 multiancestry biobanks across 6 countries, that genetic factors previously associated with BMI have limited impact on GLP-1 receptor agonist-induced weight loss.

GPCR dynamics are critical for signal transmission into the cell. Here, the authors probe receptor plasticity using molecular dynamics simulations, enabling the detection of allosteric sites and drug entry gateways for a broad range of GPCR types.

Four decades after a test mining experiment that removed nodules, the biological impacts in many groups of organisms persist, although populations of several organisms have begun to re-establish despite persistent physical changes at the seafloor.

Agroforestry is a natural climate solution providing ecological and socio-economic benefits at local scales, however whether it reduces deforestation at landscape scale is still unclear. Authors use causal inference to examine the effects of agroforestry on deforestation across Southeast Asia.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

Each individual is unique and so is their brain activity. Using brain fingerprinting from functional MRI during anaesthesia, Luppi et al. find that human brains become temporarily more difficult to identify and tell apart when unconscious.

Among contemporary threats to mountain biodiversity, biological invasions have been understudied. This large-scale synthesis on alien vertebrates in global mountains delves into their distribution, biogeographic flows, presence in Protected Areas, and key predictors of such patterns.

The study reveals how bortezomib activates Mycobacterium tuberculosis Clp protease complexes. Cryo-EM structures reveal how sub-stoichiometric bortezomib binding triggers structural changes, mediates holoenzyme formation and disrupts Clp system regulation.

This systematic review and meta-analysis provides an updated assessment of the efficacy and safety of intravenous iron therapy in patients with heart failure and iron deficiency, incorporating the results of the newly conducted FAIF-HF2 trial.

Illness signals from the gut reactivate and strengthen flavour representations in the amygdala to support learning from delayed postingestive feedback.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Dense calcium imaging combined with co-registered high-resolution electron microscopy reconstruction of the brain of the same mouse provide a functional connectomics map of tens of thousands of neurons of a region of the primary cortex and higher visual areas.

Bhattacharjee and Schaeffer et al. map exclusive breastfeeding (EBF) in 94 low- and middle-income countries (LMICs), finding increased EBF practice and reduced subnational variation across the majority of LMICs from 2000 to 2018. However, only six LMICs will meet WHO’s target of ≥70% EBF by 2030 nationally, and only three will achieve this in all districts.

High-dose oral vitamin D₃ supplements have previously been shown to be beneficial in children receiving standard therapy for uncomplicated severe acute malnutrition. This randomised controlled trial shows that the same intervention, given in addition to standard therapy, did not improve anthropometric or neurodevelopmental outcomes in children with complicated severe acute malnutrition in Pakistan.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

Monolayer graphene can support the quantum Hall effect up to room temperature. Here, the authors provide evidence that graphene encapsulated in hexagonal boron nitride realizes a novel transport regime where dissipation in the quantum Hall phase is mediated predominantly by electron-phonon scattering rather than disorder scattering.

Spontaneous parametric down-conversion was used to generate narrowband photon pairs with a high spectral brightness in a high-Q silicon nitride microresonator.

To reveal cellular mechanisms of cognitive decline after stroke the authors established an experimental paradigm in mice monitoring individual nerve cells involved in spatial memory in health and disease allowing to identify functional biomarkers.

Here the authors use mRNA display to discover peptide inhibitors of BamA, an essential factor that catalyzes the membrane insertion of bacterial outer membrane proteins. They show that three peptides are antibacterial and inhibit BamA activity by a unique mechanism.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

Fatty liver disease exacerbates atherosclerosis, but the underlying mechanisms remain unclear. Here, the authors show that D-dopachrome tautomerase (D-DT/MIF-2) acts as an atypical chemokine, promoting both atherosclerosis and hepatic lipid accumulation.

Terahertz-frequency vibrational modes are thought to play a key role for DNA biological functions, yet observation of these fluctuations in solution has proven difficult so far. Here, the authors use femtosecond optical Kerr-effect spectroscopy to demonstrate their existence in physiologically relevant conditions.

Here the authors report results from a randomized clinical trial testing a combination of ChAOx1/MVA.HTI vaccines and the TLR7 agonist vesatolimod in men living with HIV-1. While the treatment showed a good safety profile and induction of HTI-focused T-cell responses, viral rebound was similar in treatment arm and placebo arm.

Phosphatase enzymes are challenging to study due to a lack of specific inhibitors. Here, authors develop a chemical-genetic system to inhibit and characterize a major Ser/Thr phosphatase complex, and suggest this strategy, termed directSLiMs, could be used to inhibit other “undruggable” enzymes.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

Next-generation proton exchange membrane electrolyzers rely on high-performance anodes. Here, the authors report a metal-oxide-based molecular self-assembly strategy toward a support-free iridium hydroxide catalyst for an advanced anode with low-iridium loading and enhanced mass transport.

The reasons for epistasis, wherein mutations interact non-additively, are often not fully understood. Now it is found that shifting the rate-limiting step from substrate binding to the chemical reaction step during the directed evolution of β-lactamase correlates with epistasis.

Bio-inspired Ni-based molecular catalysts are efficient for H₂ oxidation, but are suffering from the poor stability in the presence of O₂. Here, the authors develop a strategy to boost greatly their stability by dispersing them in a hydrophobic and redox-silent polymer matrix.

NGPS is an accelerated aging condition, caused by a mutation in BAF. Here, we report the results of an unbiased, whole genome CRISPR microscopy screen aimed at restoring nuclear envelope integrity in NGPS patient cells.

In this paper, translation fidelity was assessed across aging in knock-in mice with a mistranslation reporter which determines stop codon readthrough. Age-related increases in translational errors were observed in muscle and brain, but not in liver, highlighting organ-dependent declines in translation fidelity as a possible contributor to aging.

When hominins dispersed into Eurasia is unclear. Here, the authors present multiple cut-marked bones from Grăunceanu, Romania dated to at least 1.95 million years ago and suggest hominins would have lived in a temperate and seasonal environment.