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Evolution of iGluR ligand specificity, polyamine regulation, and ion selectivity inferred from a placozoan epsilon receptor

The authors generated a species-guided phylogeny of eukaryotic iGluRs, alongside a focused analysis of iGluR homologues from the early-branching invertebrate phylum Placozoa.

Anhadvir Singh
Boris S. Zhorov
Adriano Senatore
ResearchOpen Access03 Jul 2025
Communications Biology

Volume: 8, P: 1-23
A conformational switch controlling the toxicity of the prion protein

The H-latch is a well-defined structural change occurring in PrP^C bound to the neurotoxic antibody POM1, and its presence shows a positive correlation with neurotoxicity. Inhibition of the H-latch prolongs the lifespan of prion-diseased mice.

Karl Frontzek
Marco Bardelli
Adriano Aguzzi
ResearchOpen Access10 Aug 2022
Nature Structural & Molecular Biology

Volume: 29, P: 831-840
Function and phylogeny support the independent evolution of an ASIC-like Deg/ENaC channel in the Placozoa

The non-bilaterian Trichoplax adhaerens has a proton-activated Deg/ENaC channel with ASIC-like biophysical properties but distinct determinants for proton gating. Phylogenetic evidence for the existence of Deg/ENaC channels outside of animals is also provided.

Wassim Elkhatib
Luis A. Yanez-Guerra
Adriano Senatore
ResearchOpen Access18 Sept 2023
Communications Biology

Volume: 6, P: 1-20
Mint/X11 PDZ domains from non-bilaterian animals recognize and bind Ca_V2 calcium channel C-termini in vitro

Alicia N. Harracksingh
Anhadvir Singh
Adriano Senatore
ResearchOpen Access16 Sept 2024
Scientific Reports

Volume: 14, P: 1-27
The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6

The cellular prion protein PrP^C promotes peripheral myelin homeostasis by acting on a G protein-coupled receptor to increase levels of cyclic AMP in Schwann cells.

Alexander Küffer
Asvin K. K. Lakkaraju
Adriano Aguzzi
Research08 Aug 2016
Nature

Volume: 536, P: 464-468
Author Correction: Brain aging is faithfully modelled in organotypic brain slices and accelerated by prions

Yingjun Liu
Assunta Senatore
Adriano Aguzzi
Amendments and CorrectionsOpen Access20 Jun 2022
Communications Biology

Volume: 5, P: 1
Brain aging is faithfully modelled in organotypic brain slices and accelerated by prions

Cultured brain slices from mice spontaneously upregulate senescence-associated genes over time and reproduce the transcriptional characteristics of aged brains; prions accelerate brain aging in brain slice cultures, animal models and human patients.

Yingjun Liu
Assunta Senatore
Adriano Aguzzi
ResearchOpen Access08 Jun 2022
Communications Biology

Volume: 5, P: 1-11

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Evolution of iGluR ligand specificity, polyamine regulation, and ion selectivity inferred from a placozoan epsilon receptor

A conformational switch controlling the toxicity of the prion protein

Function and phylogeny support the independent evolution of an ASIC-like Deg/ENaC channel in the Placozoa

Mint/X11 PDZ domains from non-bilaterian animals recognize and bind CaV2 calcium channel C-termini in vitro

The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6

Author Correction: Brain aging is faithfully modelled in organotypic brain slices and accelerated by prions

Brain aging is faithfully modelled in organotypic brain slices and accelerated by prions

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Mint/X11 PDZ domains from non-bilaterian animals recognize and bind Ca_V2 calcium channel C-termini in vitro