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Advanced filters: Author: Adrija Pathak Clear advanced filters

  • Type 2 diabetes (T2D) is characterized by pancreatic beta-cell failure. Here, the authors show restoration of Phosphatidylinositol transfer protein alpha (PITPNA), a mediator of PtdIns-4-phosphate synthesis in the trans-Golgi network, in human T2D islets reverses impaired insulin granule maturation, exocytosis, and ER stress.

    • Yu-Te Yeh
    • Chandan Sona
    • Matthew N. Poy
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19